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Metastatic Pancreatic Adenocarcinoma

An adenocarcinoma that arises from the exocrine pancreatic tissue and has metastasized to other anatomic sites.
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
PURPOSE GVAX pancreas, granulocyte-macrophage colony-stimulating factor-secreting allogeneic pancreatic tumor cells, induces T… Expand
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Highly Cited
2014
Highly Cited
2014
BACKGROUND Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition… Expand
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Highly Cited
2014
Highly Cited
2014
Purpose: The hedgehog (HH) signaling pathway is a key regulator in tumorigenesis of pancreatic adenocarcinoma and is upregulated… Expand
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Highly Cited
2011
Highly Cited
2011
PURPOSE The trial objectives were to identify the maximum-tolerated dose (MTD) of first-line gemcitabine plus nab-paclitaxel in… Expand
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Highly Cited
2010
Highly Cited
2010
New, effective therapies are needed for pancreatic ductal adenocarcinoma. Ipilimumab can mediate an immunologic tumor regression… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE Patients with advanced pancreas cancer present with disease that is poorly responsive to conventional therapies… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND & AIMS The infiltrating ductal adenocarcinoma of the pancreas is among the most lethal of all solid malignancies… Expand
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Highly Cited
2008
Highly Cited
2008
CONTEXT Among patients with locally advanced metastatic pancreatic adenocarcinoma, gemcitabine has been shown to improve outcomes… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Gemcitabine is an active antitumor agent in the treatment of advanced pancreatic cancer, and has shown potential… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND A prospective, randomized Phase III trial was performed to determine whether, compared with gemcitabine (GEM) alone… Expand
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