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Metastatic Pancreatic Adenocarcinoma

An adenocarcinoma that arises from the exocrine pancreatic tissue and has metastasized to other anatomic sites.
National Institutes of Health

Related topics

Related topics

14 relations
Abdominal PainDiabetes MellitusEpithelial CellsEpithelium
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Papers overview

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Highly Cited
2015
Highly Cited
2015
Safety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.
PURPOSE GVAX pancreas, granulocyte-macrophage colony-stimulating factor-secreting allogeneic pancreatic tumor cells, induces T… Expand
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Highly Cited
2014
Highly Cited
2014
Phase II and pharmacodynamic study of autophagy inhibition using hydroxychloroquine in patients with metastatic pancreatic adenocarcinoma.
BACKGROUND Autophagy is a catabolic pathway that permits cells to recycle intracellular macromolecules, and its inhibition… Expand
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Highly Cited
2014
Highly Cited
2014
Pilot Clinical Trial of Hedgehog Pathway Inhibitor GDC-0449 (Vismodegib) in Combination with Gemcitabine in Patients with Metastatic Pancreatic Adenocarcinoma
Purpose: The hedgehog (HH) signaling pathway is a key regulator in tumorigenesis of pancreatic adenocarcinoma and is upregulated… Expand
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Highly Cited
2011
Highly Cited
2011
Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial.
PURPOSE The trial objectives were to identify the maximum-tolerated dose (MTD) of first-line gemcitabine plus nab-paclitaxel in… Expand
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Highly Cited
2010
Highly Cited
2010
Phase 2 Trial of Single Agent Ipilimumab (Anti-CTLA-4) for Locally Advanced or Metastatic Pancreatic Adenocarcinoma
New, effective therapies are needed for pancreatic ductal adenocarcinoma. Ipilimumab can mediate an immunologic tumor regression… Expand
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Highly Cited
2010
Highly Cited
2010
Phase III study comparing gemcitabine plus cetuximab versus gemcitabine in patients with advanced pancreatic adenocarcinoma: Southwest Oncology Group-directed intergroup trial S0205.
PURPOSE Patients with advanced pancreas cancer present with disease that is poorly responsive to conventional therapies… Expand
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Highly Cited
2009
Highly Cited
2009
Retinoic acid receptor antagonists inhibit miR-10a expression and block metastatic behavior of pancreatic cancer.
BACKGROUND & AIMS The infiltrating ductal adenocarcinoma of the pancreas is among the most lethal of all solid malignancies… Expand
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Highly Cited
2008
Highly Cited
2008
Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial.
CONTEXT Among patients with locally advanced metastatic pancreatic adenocarcinoma, gemcitabine has been shown to improve outcomes… Expand
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Highly Cited
2003
Highly Cited
2003
Biweekly high-dose gemcitabine alone or in combination with capecitabine in patients with metastatic pancreatic adenocarcinoma: a randomized phase II trial.
BACKGROUND Gemcitabine is an active antitumor agent in the treatment of advanced pancreatic cancer, and has shown potential… Expand
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Highly Cited
2002
Highly Cited
2002
Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized phase III study of the Gruppo Oncologia dell…
BACKGROUND A prospective, randomized Phase III trial was performed to determine whether, compared with gemcitabine (GEM) alone… Expand
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