Metaplasia

Known as: Metaplasia [Disease/Finding], Metaplastic Change, metaplasis 
Transformation of a mature, normal cell or groups of mature cells to other forms of mature cells. The capacity for malignant transformation of… (More)
National Institutes of Health

Related topics

Related topics

27 relations
Barrett EsophagusBarrett's AdenocarcinomaBladder Squamous Cell CarcinomaCDISC SEND Non-Neoplastic Finding Type Terminology
(More)

Narrower (3)

Biological MetamorphosisMyeloid Metaplasiacervical metaplasia

Broader (1)

Signs and Symptoms

Papers overview

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Highly Cited
2011
Highly Cited
2011
Residual Embryonic Cells as Precursors of a Barrett's-like Metaplasia
Barrett's esophagus is an intestine-like metaplasia and precursor of esophageal adenocarcinoma. Triggered by gastroesophageal… (More)
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Highly Cited
2009
Highly Cited
2009
Notch signaling promotes airway mucous metaplasia and inhibits alveolar development.
The airways are conduits that transport atmospheric oxygen to the distal alveolus. Normally, airway mucous cells are rare… (More)
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Highly Cited
2007
Highly Cited
2007
Induction of high-affinity IgE receptor on lung dendritic cells during viral infection leads to mucous cell metaplasia
Respiratory viral infections are associated with an increased risk of asthma, but how acute Th1 antiviral immune responses lead… (More)
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Highly Cited
2006
Highly Cited
2006
MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia
BACKGROUND The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis… (More)
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Highly Cited
2006
Highly Cited
2006
Blocking airway mucous cell metaplasia by inhibiting EGFR antiapoptosis and IL-13 transdifferentiation signals.
Epithelial hyperplasia and metaplasia are common features of inflammatory and neoplastic disease, but the basis for the altered… (More)
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Highly Cited
2004
Highly Cited
2004
Modulation of notch processing by gamma-secretase inhibitors causes intestinal goblet cell metaplasia and induction of genes known to specify gut secretory lineage differentiation.
It is anticipated that gamma-secretase inhibitors (gamma-Sec-I) that modulate Notch processing will alter differentiation in… (More)
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Highly Cited
2002
Highly Cited
2002
Matrix metalloproteinase-7 is expressed by pancreatic cancer precursors and regulates acinar-to-ductal metaplasia in exocrine pancreas.
In gastrointestinal epithelium, metaplastic conversion between predominant cell types is associated with an increased risk of… (More)
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Highly Cited
2001
Highly Cited
2001
Cyclooxygenase-2 expression in the Barrett's metaplasia–dysplasia–adenocarcinoma sequence
OBJECTIVE:Increased expression of the inducible cyclooxygenase 2 (COX-2) enzyme has been detected in esophageal and colonic… (More)
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Highly Cited
2000
Highly Cited
2000
Barrett's metaplasia
The rate of oesophageal adenocarcinoma is increasing in the western world and has a poor prognosis mainly because individuals… (More)
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Highly Cited
1999
Highly Cited
1999
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.
Interleukin (IL)-13 is a pleiotropic cytokine produced in large quantities by activated CD4(+) Th2 lymphocytes. To define further… (More)
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