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Mendelian Randomization Analysis

Known as: Analysis, Mendelian Randomization 
The use of the GENETIC VARIATION of known functions or phenotypes to correlate the causal effects of those functions or phenotypes with a disease… 
National Institutes of Health

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Papers overview

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Highly Cited
2019
Highly Cited
2019
Associations Between Measures of Sarcopenic Obesity and Risk of Cardiovascular Disease and Mortality: A Cohort Study and Mendelian Randomization Analysis Using the UK Biobank
Background The “healthy obese” hypothesis suggests the risks associated with excess adiposity are reduced in those with higher… 
2019
2019
Conducting a Reproducible Mendelian Randomization Analysis Using the R Analytic Statistical Environment
Mendelian randomization (MR) is defined as the utilization of genetic variants as instrumental variables to assess the causal… 
2019
2019
Body composition and atrial fibrillation: a Mendelian randomization study
AIMS Increases in fat-free mass and fat mass have been associated with higher risk of atrial fibrillation (AF) in observational… 
2018
2018
Serum magnesium levels and risk of coronary artery disease: Mendelian randomisation study
BackgroundObservational studies have shown that serum magnesium levels are inversely associated with risk of cardiovascular… 
2018
2018
Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome
Gene expression varies markedly across the menstrual cycle and expression levels for many genes are under genetic control. We… 
Highly Cited
2017
Highly Cited
2017
Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study
Objective To test the hypothesis that low density lipoprotein (LDL) cholesterol due to genetic variation in the genes responsible… 
Highly Cited
2017
Highly Cited
2017
Low LDL cholesterol, PCSK9 and HMGCR genetic variation, and risk of Alzheimer’s disease and Parkinson’s disease: Mendelian randomisation study
ObjeCtive To test the hypothesis that low density lipoprotein (LDL) cholesterol due to genetic variation in the genes responsible… 
Highly Cited
2016
Highly Cited
2016
Using Mendelian randomization to investigate a possible causal relationship between adiposity and increased bone mineral density at different skeletal sites in children
Background: Lean mass is positively associated with bone mineral density (BMD). However, the relationship between adiposity and… 
Review
2016
Review
2016
A Systematic Review of Biomarkers and Risk of Incident Type 2 Diabetes: An Overview of Epidemiological, Prediction and Aetiological Research Literature
Background Blood-based or urinary biomarkers may play a role in quantifying the future risk of type 2 diabetes (T2D) and in… 
Highly Cited
2010
Highly Cited
2010
HLA genotyping in the international Type 1 Diabetes Genetics Consortium
Background Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes… 
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