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Membrane Localization Motif

Known as: Membrane Localization Domain 
An amino acid sequence that directs a protein to become localized in or at the cell membrane. This targeting is determined either by the presence of… 
National Institutes of Health

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ARHI protein, human

Papers overview

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2017
2017
The membrane localization domains of two distinct bacterial toxins form a 4‐helix‐bundle in solution
Membrane localization domain (MLD) was first proposed for a 4‐helix‐bundle motif in the crystal structure of the C1 domain of… 
2014
2014
A Multifunctional Region of the Shigella Type 3 Effector IpgB1 Is Important for Secretion from Bacteria and Membrane Targeting in Eukaryotic Cells
Type 3 secretion systems are complex nanomachines used by many Gram–negative bacteria to deliver tens of proteins (effectors… 
2014
2014
Interfacial residues of SpcS chaperone affects binding of effector toxin ExoT in Pseudomonas aeruginosa: novel insights from structural and computational studies
ExoT belongs to the family of type 3 secretion system (T3SS) effector toxins in Pseudomonas aeruginosa, known to be one of the… 
2013
2013
Glycogen Synthase Kinase 3 influences cell motility and chemotaxis by regulating PI3K membrane localization in Dictyostelium
Glycogen Synthase Kinase 3 (GSK3) is a multifunctional kinase involved in diverse cellular activities such as metabolism… 
2007
2007
Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS
Pseudomonas aeruginosa ExoS (453 amino acids) is a bifunctional type III cytotoxin, comprising a Rho GTPase‐activating protein… 
2007
2007
Intracellular Localization of Type III-delivered Pseudomonas ExoS with Endosome Vesicles*
ExoS (453 amino acids) is a bi-functional type III cytotoxin produced by Pseudomonas aeruginosa. Residues 96-219 include the Rho… 
2006
2006
The discovery of SycO reveals a new function for type three secretion effector chaperones
The Type Three Secretion (T3S) system is a device used by many Gram-negative pathogens that allows bacteria to deliver effector… 
2005
2005
A Leucine-Rich Motif Targets Pseudomonas aeruginosa ExoS within Mammalian Cells
ABSTRACT Type III cytotoxins contribute to the ability of bacterial pathogens to subvert the host innate immune system. ExoS (453… 
2003
2003
Molecular heterogeneity of a type III cytotoxin, Pseudomonas aeruginosa exoenzyme S.
Pseudomonas aeruginosa ExoS is a bifunctional type III cytotoxin. The N-terminus (residues 1-232) is a Rho GTPase activating… 
Highly Cited
2000
Highly Cited
2000
Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts
The Shc adaptor is responsible for coupling receptor tyrosine kinases and tyrosine kinase-associated receptors to the Ras/MAP… 
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