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Membrane-Disrupting Peptide EP-100

Known as: EP-100 
A water-soluble, positively charged fusion protein consisting of a luteinizing hormone releasing hormone (LHRH) receptor-targeting ligand conjugated… 
National Institutes of Health

Papers overview

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2017
2017
Targeted Oncolytic Peptide for Treatment of Ovarian Cancers
First generation targeted oncolytic peptides consisted of synthetic lytic peptides conjugated to human chorionic gonadotropin or… 
2017
2017
Targeted Oncolytic Peptide for Treatment of Ovarian
Aim: EP-100 is a novel, LHRH receptor targeted cytolytic peptide conjugate designed to specifically kill LHRH receptor positive… 
2015
2015
EP-100 + paclitaxel to overcome taxane resistance in patients with recurrent LHRH-receptor expressing ovarian cancer.
5582 Background: EP-100 (E) is a synthetic cytolytic peptide conjugated to Luteinizing Hormone Releasing Hormone (LHRH). It… 
2013
2013
Abstract 978: Synergistic activity of EP-100 and chemotherapies in cancer cell lines.
EP-100, a targeted anti-cancer drug comprised of a lytic peptide fused to Luteinizing Hormone Releasing Hormone (LHRH), is in… 
2012
2012
Abstract 3715: EP-100 syndergizes with paclitaxel in ovarian, breast and prostate cancer cell lines
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL EP-100 is a targeted anti-cancer drug comprised of… 
2012
2012
A phase I study of EP-100, a luteinizing hormone releasing hormone (LHRH) ligand conjugated to a synthetic cytolytic peptide in patients with advanced refractory LHRH- receptor (R)-expressing tumors.
3060 Background: EP-100 is a synthetic 28 amino acid LHRH peptide conjugated to an 18 aa cytolytic peptide. Selective targeting… 
2011
2011
Abstract 3522: Pre-treatment with FSH enhances the ability of EP-100 to target and destroy human pancreatic cancer cells
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL The expression of luteinizing hormone releasing hormone… 
2009
2009
Modification of β-galactosidase for use in organic mono-phase hexanol system
Different methods for preparation of the Aspergillus oryzae β-galactosidase were evaluated and the total enzyme activity was… 
2009
2009
Enantioselective behavior of lipases from Aspergillus niger immobilized in different supports
Considering the extraordinary microbial diversity and importance of fungi as enzyme producers, the search for new biocatalysts… 
2000
2000
Immobilisation of lipases by adsorption and deposition: high protein loading gives lower water activity optimum
Two different immobilisation techniques for lipases were investigated: adsorption on to Accurel EP-100 and deposition on to… 
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