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Melogliptin

Known as: (2S,4S)-4-Fluoro-1-(2-(((1R,3S)-3-((1H-1,2,4-Triazol-1-yl)Methyl)Cyclopentyl)Amino)Acetyl)Pyrrolidine-2-Carbonitrile 
A potent, selective and orally bioavailable, cyanopyrrolidine-based inhibitor of dipeptidyl peptidase 4 (DPP-4), with hypoglycemic activity.
National Institutes of Health

Papers overview

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2012
2012
Ligand-based pharmacophore detection, screening of potential gliptins and docking studies to get effective antidiabetic agents.
Three-dimensional pharmacophore hypothesis was established based on a set of known DPP-IV inhibitor using PharmaGist software… 
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