Megakaryocyte Progenitor Cells
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Infections are associated with extensive platelet consumption, representing a high risk for health. However, the mechanism… Expand The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs. To address this issue, we developed… Expand Platelets have a key role in atherogenesis and its complications. Both hypercholesterolemia and increased platelet production… Expand The production of hematopoietic cells is under the tight control of a group of hematopoietic cytokines. Each cytokine has… Expand In the adult, platelets are derived from unipotential megakaryocyte colony-forming cells (Meg-CFCs) that arise from bipotential… Expand The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is… Expand The molecular pathways involved in the differentiation of hematopoietic progenitors are unknown. Here we report that chemokine… Expand Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that acts as a stimulator of pre-B lymphocyte cell growth and as a… Expand Thrombocytopenia is an important clinical problem in the management of patients in hematology and oncology practices. In the… Expand Thrombopoietin (TPO) is a recently identified growth factor that regulates megakaryocytopoiesis. Its receptor, c-Mpl, is… Expand