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Megakaryocyte Progenitor Cells

Known as: Cell, Megakaryocyte Progenitor, Progenitor, Megakaryocyte, Progenitor Cell, Megakaryocyte 
The parent cells that give rise to cells in the MEGAKARYOCYTE lineage, and ultimately BLOOD PLATELETS.
National Institutes of Health

Related topics

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6 relations
MegakaryoblastsMicrobiologicalProcess of secretionPromegakaryocytes
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Papers overview

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Highly Cited
2015
Highly Cited
2015
Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.
Infections are associated with extensive platelet consumption, representing a high risk for health. However, the mechanism… Expand
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Highly Cited
2014
Highly Cited
2014
Expandable megakaryocyte cell lines enable clinically applicable generation of platelets from human induced pluripotent stem cells.
The donor-dependent supply of platelets is frequently insufficient to meet transfusion needs. To address this issue, we developed… Expand
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Highly Cited
2013
Highly Cited
2013
Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis
Platelets have a key role in atherogenesis and its complications. Both hypercholesterolemia and increased platelet production… Expand
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Highly Cited
2007
Highly Cited
2007
The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis.
In the adult, platelets are derived from unipotential megakaryocyte colony-forming cells (Meg-CFCs) that arise from bipotential… Expand
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Review
2005
Review
2005
The bone marrow vascular niche: home of HSC differentiation and mobilization.
The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is… Expand
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Highly Cited
2004
Highly Cited
2004
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
The molecular pathways involved in the differentiation of hematopoietic progenitors are unknown. Here we report that chemokine… Expand
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Highly Cited
2002
Highly Cited
2002
Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling
Fibrinogen binding to integrin αIIbβ3 mediates platelet aggregation and requires agonist-induced “inside-out” signals that… Expand
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Highly Cited
2000
Highly Cited
2000
Stromal cell-derived factor-1 (SDF-1) acts together with thrombopoietin to enhance the development of megakaryocytic progenitor cells (CFU-MK).
Stromal cell-derived factor-1 (SDF-1) is a CXC chemokine that acts as a stimulator of pre-B lymphocyte cell growth and as a… Expand
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Highly Cited
1995
Highly Cited
1995
Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin.
Thrombopoietin (TPO) is a recently identified growth factor that regulates megakaryocytopoiesis. Its receptor, c-Mpl, is… Expand
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1992
1992
Megakaryocytes and Megakaryocyte Progenitors in Human Cord Blood
Thrombocytopenia contributes significantly to morbidity in the sick term or preterm infant. However, few data exist on newborn's… Expand
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