Megakaryocyte Progenitor Cells

Known as: Cell, Megakaryocyte Progenitor, Progenitor, Megakaryocyte, Progenitor Cell, Megakaryocyte 
The parent cells that give rise to cells in the MEGAKARYOCYTE lineage, and ultimately BLOOD PLATELETS.
National Institutes of Health

Related topics

Related topics

6 relations
MegakaryoblastsMicrobiologicalProcess of secretionPromegakaryocytes
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.
Infections are associated with extensive platelet consumption, representing a high risk for health. However, the mechanism… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2013
Highly Cited
2013
Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and thrombocytosis
Platelets have a key role in atherogenesis and its complications. Both hypercholesterolemia and increased platelet production… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2009
Highly Cited
2009
GATA-2 reinforces megakaryocyte development in the absence of GATA-1.
GATA-2 is an essential transcription factor that regulates multiple aspects of hematopoiesis. Dysregulation of GATA-2 is a… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2007
Highly Cited
2007
The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis.
In the adult, platelets are derived from unipotential megakaryocyte colony-forming cells (Meg-CFCs) that arise from bipotential… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • figure 4
Is this relevant?
2006
2006
Mammalian target of rapamycin (mTOR) regulates both proliferation of megakaryocyte progenitors and late stages of megakaryocyte differentiation.
A major determinant in platelet production is the megakaryocyte (MK) size that is regulated both by ploidization and the increase… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2004
Highly Cited
2004
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
The molecular pathways involved in the differentiation of hematopoietic progenitors are unknown. Here we report that chemokine… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Megakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.
Fibrinogen binding to integrin alphaIIbbeta3 mediates platelet aggregation and requires agonist-induced "inside-out" signals that… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
The alpha-chemokine receptor CXCR4 is expressed on the megakaryocytic lineage from progenitor to platelets and modulates migration and adhesion.
CXCR4 is the receptor for the alpha-chemokine stromal cell-derived factor 1 (SDF-1) and has been shown to be expressed on a… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Platelets generated in vitro from proplatelet-displaying human megakaryocytes are functional.
An in vitro culture system demonstrating the transitions from megakaryocyte progenitors to functional platelets is described… (More)
  • figure 2
  • figure 3
  • figure 5
  • figure 4
  • figure 6
Is this relevant?
1982
1982
Immature megakaryocytes in the mouse: in vitro relationship to megakaryocyte progenitor cells and mature megakaryocytes.
An assay describing conditions for the maturation of single immature megakaryocytes in vitro is reported. Enriched populations of… (More)
Is this relevant?