Mechanism of Cell Death

A biological process that results in permanent cessation of all vital functions of a cell.(Gene Ontology)
National Institutes of Health

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Highly Cited
2006
Highly Cited
2006
A mechanism of cell death involving an adenylyl cyclase/PKA signaling pathway is induced by the Cry1Ab toxin of Bacillus thuringiensis.
Many pathogenic organisms and their toxins target host cell receptors, the consequence of which is altered signaling events that… (More)
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2006
2006
Mechanism of cell death induction by nitroxide and hyperthermia.
Heat stress and nitroxides induce reactive oxygen species (ROS) and proapoptotic effects. The underlying mechanisms remain… (More)
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Highly Cited
2004
Highly Cited
2004
Use of multiple assay endpoints to investigate the effects of incubation time, dose of toxin, and plating density in cell-based cytotoxicity assays.
Here we show the results of comparing cell viability, cytotoxicity, and apoptosis assays for measuring the time- and dose… (More)
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Highly Cited
2003
Highly Cited
2003
The mechanism of cell death during West Nile virus infection is dependent on initial infectious dose
Received 20 June 2003 Accepted 20 August 2003 The mechanism of West Nile (WN) virus-induced cell death is determined by the… (More)
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Highly Cited
2002
Highly Cited
2002
Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death
Nutrient deprivation has been shown to cause cancer cell death. To exploit nutrient deprivation as anti-cancer therapy, we… (More)
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Highly Cited
2001
Highly Cited
2001
Mechanism of cell death during warm hepatic ischemia-reperfusion in rats: apoptosis or necrosis?
Reperfusion injury can cause liver dysfunction after cold storage and warm ischemia. Recently it has been suggested that more… (More)
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Highly Cited
1998
Highly Cited
1998
Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression
In situ killing of tumor cells using suicide gene transfer to generate death by a non-apoptotic pathway was associated with high… (More)
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Highly Cited
1991
Highly Cited
1991
Apoptosis as a mechanism of cell death in cultured T lymphoblasts acutely infected with HIV-1.
The mechanisms by which HIV-1 infection kills T lymphocytes are not clearly established. Apoptosis is an internally programmed… (More)
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Highly Cited
1991
Highly Cited
1991
Mechanism of cell death following thymidylate synthase inhibition: 2'-deoxyuridine-5'-triphosphate accumulation, DNA damage, and growth inhibition following exposure to CB3717 and dipyridamole.
The thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) inhibits the growth of human lung carcinoma A549… (More)
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Highly Cited
1987
Highly Cited
1987
Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death.
The mechanism of cytotoxic action of 5-fluorodeoxyuridine (FdUrd) in mouse FM3A cells was investigated. We observed the FdUrd… (More)
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