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Mannich Bases

Known as: Bases, Mannich, Mannich Bases [Chemical/Ingredient], Mannich base 
Ketonic amines prepared from the condensation of a ketone with formaldehyde and ammonia or a primary or secondary amine. A Mannich base can act as… 
National Institutes of Health

Related topics

Related topics

10 relations

Broader (1)

Amines
In Bloodagonistsantagonists & inhibitorsaspects of radiation effects

Narrower (3)

NC 1153NC 1175NC 758

Papers overview

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Highly Cited
2013
Highly Cited
2013
Ionic liquids as unique solvents in one-pot synthesis of 4-(n,2,2,2-tetranitroethylamino)-3-R-furazans.
An efficient two-step one-pot protocol for the synthesis of N-nitrated trinitroethylamino furazans in an ionic liquid has been… 
Highly Cited
2010
Highly Cited
2010
Modular synthesis and in vitro and in vivo antimalarial assessment of C-10 pyrrole mannich base derivatives of artemisinin.
In two steps from dihydroartemisinin, a small array of 16 semisynthetic C-10 pyrrole Mannich artemisinin derivatives (7a-p) have… 
2005
2005
Synthesis of chiral vicinal diamines by highly diastereoselective three-component phenolic Mannich reaction: temperature-dependent stereodivergency.
[reaction: see text] A diastereoselective three-component synthesis of chiral o-1,2-diaminoalkyl phenols from an electron-rich… 
2005
2005
Asymmetric aza-Mannich reactions of sulfinimines: scope and application to the total synthesis of a bromopyrrole alkaloid.
[reaction: see text] An asymmetric intermolecular aza variant of the Mannich reaction is reported utilizing chiral sulfinimine… 
Highly Cited
2001
Highly Cited
2001
Synthesis of Mannich Bases of Some 2,5‐Disubstituted 4‐Thiazolidinones and Evaluation of Their Antimicrobial Activities
5‐Phenyl/methyl‐5‐morpholinomethyl/pyrrolidinomethyl‐2‐(5‐aryl‐1,3,4‐oxadiazol‐2‐yl) imino]‐4‐thiazolidinones (5a—m) were… 
2001
2001
Antifungal Activity of Some Mono, Bis and Quaternary Mannich Bases Derived from Acetophenone
Summary The development of resistance to current antifungal therapeutics drives search for new effective agents. Some Mannich… 
1994
1994
Antimicrobial evaluation of some styryl ketone derivatives and related thiol adducts.
Acyclic alpha,beta-unsaturated ketones were synthesized and treated with either 2-mercaptoethanol or cystenamine hydrochloride… 
Highly Cited
1984
Highly Cited
1984
Synthesis and antibacterial activity of some 5-nitro-3-phenyliminoindol-2(3H)-ones and their N-Mannich bases.
The antimicrobial and antifungal activities of a series of 5-nitro-3-phenyliminoindol-2(3H)-ones and their 1-piperidinomethyl… 
Highly Cited
1967
Highly Cited
1967
Adenovirus antigens--a study of their properties and sequential development in infection.
Summary Antisera were prepared which reacted specifically with different antigens in the capsid of adenovirus type 5, viz. hexons… 
Highly Cited
1967
Highly Cited
1967
Effects of quaternary bases and inorganic cations on acetylcholine synthesis in nervous tissue.
A number of quaternary bases were tested for their ability to inhibit the synthesis of acetylcholine (ACh) by incubated minced… 
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