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MVT 101

Known as: L-Argininamide, N-(2-((N-(N-acetyl-L-threonyl)-L-isoleucyl)amino)hexyl)-L-norleucyl-L-glutaminyl-, (S)-, MVT-101 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2007
0119922007

Related topics

Related topics

1 relation

Broader (1)

Oligopeptides

Related mentions per year

Related mentions per year

1954-2018
1960198020002020
MVT 101
Oligopeptides

Papers overview

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2007
2007
Insights from atomic-resolution X-ray structures of chemically synthesized HIV-1 protease in complex with inhibitors.
The human immunodeficiency virus 1 (HIV-1) protease (PR) is an aspartyl protease essential for HIV-1 viral infectivity. HIV-1 PR… (More)
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2004
2004
X - ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate - based hydroxyethylamine inhibitor ( AIDS / retrovirus / diastereomer…
The structure of a crystal complex of the chemically synthesized protease of human immunodeficiency virus 1 with a heptapeptide… (More)
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1997
1997
Analysis of the structure of chemically synthesized HIV-1 protease complexed with a hexapeptide inhibitor. Part I: Crystallographic refinement of 2 A data.
The structure of a complex between a hexapeptide-based inhibitor, MVT-101, and the chemically synthesized (Aba 67,95,167,195; Aba… (More)
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1997
1997
Analysis of the structure of HIV-1 protease complexed with a hexapeptide inhibitor. Part II: Molecular dynamic studies of the active site region.
Six models of the catalytic site of HIV-1 protease complexed with a reduced peptide inhibitor, MVT-101, were investigated. These… (More)
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1996
1996
Empirical free energy calculations of human immunodeficiency virus type 1 protease crystallographic complexes. II. Knowledge-based ligand-protein interaction potentials applied to thermodynamic…
Empirical free energy calculations of HIV-1 protease crystallographic complexes based on the developed knowledge-based ligand… (More)
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1995
1995
Development of pseudopeptide inhibitors of HIV-1 aspartic protease: analysis and tuning of the subsite specificity.
HIV-1 aspartic protease (PR) is a promising target for acquired immunodeficiency syndrome (AIDS) therapy, and the development of… (More)
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1994
1994
Crystal-structure-based design and synthesis of novel C-terminal inhibitors of HIV protease.
The X-ray crystal-structure-based design, synthesis, computational evaluation, and activity of a novel class of HIV protease… (More)
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1993
1993
Multiple copy simultaneous search and construction of ligands in binding sites: application to inhibitors of HIV-1 aspartic proteinase.
Rational ligand design is a complex problem that can be divided into three parts: the search for optimal positions and… (More)
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1993
1993
Catalytic contribution of flap-substrate hydrogen bonds in "HIV-1 protease" explored by chemical synthesis.
An analogue of "HIV-1 protease" was designed in which the ability to donate important water-mediated hydrogen bonds to substrate… (More)
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1992
1992
Molecular mechanics analysis of inhibitor binding to HIV-1 protease.
Crystallographic structures of HIV protease with three different peptide-mimetic inhibitors were subjected to energy minimization… (More)
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