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MRT67307

 
National Institutes of Health

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2 relations

Broader (2)

CyclobutanesMorpholines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Reversal of CYLD phosphorylation as a novel therapeutic approach for adult T-cell leukemia/lymphoma (ATLL)
Adult T-cell leukemia/lymphoma (ATLL) is a malignancy of mature T cells associated with chronic infection by human T-cell… Expand
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2020
2020
Polyinosinic-Polycytidylic Acid Induces CXCL1 Expression in Cultured hCMEC/D3 Human Cerebral Microvascular Endothelial Cells
Objective: Brain microvascular endothelial cells are integral components of the blood-brain barrier and play a role in protecting… Expand
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2018
2018
Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies—T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study
CYLD is a deubiquitinating enzyme that plays a crucial role in immunity and inflammation as a negative regulator of NF-κB… Expand
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2018
2018
Baicalein protects against endothelial cell injury by inhibiting the TLR4/NF-κB signaling pathway
The involvement of vascular endothelial injury with the pathophysiological process of heart failure has been identified… Expand
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2017
2017
Abstract 3460: TBK1 regulates mitotic progression by modulating spindle assembly checkpoint in cancer cells
TANK Binding Kinase 1 (TBK1) is a non-canonical IkB kinase that contributes to KRAS-driven lung cancer. It is activated by… Expand
Highly Cited
2015
Highly Cited
2015
Pharmacological Inhibition of ULK1 Kinase Blocks Mammalian Target of Rapamycin (mTOR)-dependent Autophagy*
Background: Autophagy is an intracellular lysosomal degradation pathway implicated in many diseases, but there are currently no… Expand
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Highly Cited
2011
Highly Cited
2011
Novel cross-talk within the IKK family controls innate immunity.
Members of the IKK {IκB [inhibitor of NF-κB (nuclear factor κB)] kinase} family play a central role in innate immunity by… Expand
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