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MRK 560

Known as: MRK-560, MRK560 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Sulfonamides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
PF159 COMBINATION OF SELECTIVE GAMMA-SECRETASE INHIBITOR MRK-560 WITH OTHER TARGETED THERAPY IS AN EFFECTIVE AND SAFE TREATMENT FOR T-ALL
2015
2015
Quantitative assessment of Aβ peptide in brain, cerebrospinal fluid and plasma following oral administration of γ-secretase inhibitor MRK-560 in rats
The β-amyloid peptides (Aβ) are thought to play a critical role in the pathophysiology of Alzheimer's disease. One therapeutic… 
Highly Cited
2006
Highly Cited
2006
In Vivo Characterization of Aβ(40) Changes in Brain and Cerebrospinal Fluid Using the Novel γ-Secretase Inhibitor N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1…
Plaques in the parenchyma of the brain containing Aβ peptides are one of the hallmarks of Alzheimer's disease. These Aβ peptides… 
2006
2006
The novel γ secretase inhibitor MRK-560 reduces amyloid plaque deposition without evidence of Notch-related pathology in the Tg 2576 mouse
Department of In Vivo Neuroscience (J.D.B., J.R.A.), Department of Molecular & Cellular Neuroscience (D.W.S., R.O., H.D.W., S.E… 
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