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MRK 003

Known as: MRK-003, MRK003 
National Institutes of Health

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2 relations

Broader (2)

Cyclic S-OxidesThiadiazoles

Papers overview

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2015
2015
Strong therapeutic potential of γ-secretase inhibitor MRK003 for CD44-high and CD133-low glioblastoma initiating cells
2014
2014
Triple-Negative Breast Cancer and Adenoid Cystic Carcinoma Discovery of Biomarkers Predictive of GSI Response in
Next-generation sequencing was used to identify Notch mutations in a large collection of diverse solid tumors. NOTCH1 and NOTCH2… 
2013
2013
Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells
2013
2013
[Inhibitory effects of gamma secretase inhibitor on human multiple myeloma xenograft mouse model].
OBJECTIVE To explore the tumor growth inhibition of gamma secretase inhibitor MRK003 on human multiple myeloma xenograft mice by… 
2013
2013
Drug Resistance Mechanisms to Gamma-secretase Inhibitors in Human Colon Cancer Cells
The Notch signaling pathway plays a significant role in differentiation, proliferation, apoptosis, and stem cell processes. It is… 
2013
2013
Abstract 861: Analysis of predictive genes in triple negative breast cancer in response to a gamma-secretase inhibitor.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Defined by the lack of estrogen and progesterone… 
2012
2012
Abstract 5227: Multimodality approaches to treat hypoxic NSCLC tumor microenvironment
In a previous study we found both in vitro and in an orthotropic NSCLC model in SCID mice that survival of NSCLC cells in hypoxic… 
2011
2011
Abstract 496: Notch pathway activity identifies functional lung cancer stem cells and correlates with worse survival in patients with lung adenocarcinoma
Background: The cancer stem cell hypothesis postulates that tumors contain a subset of cells with stem cell properties that can… 
2009
2009
Inhibition of Notch signaling reduces the stem-like cell population in T47D breast cancer cells and prevents mammosphere formation.
CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts Abstract #106 Breast cancer has been proposed as a stem cell… 
2009
2009
Targeting Intrinsically-Resistant Breast Cancer Stem Cells with Gamma-Secretase Inhibitors.
Background: We showed previously that tumorigenic, mammosphere-forming human breast cancer cells characterized by high CD44 and… 
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