MM-121
National Institutes of Health
Papers overview
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Purpose: Although there are many well-defined signaling pathways in tumor cells that provide druggable targets, emergence of…
Purpose: Heregulin-mediated activation of the human epidermal growth factor receptor 3 (HER3/ErbB3) is required for the growth…
The EGFR monoclonal antibody cetuximab is the only approved targeted agent for treating head and neck squamous cell carcinoma…
MM-121/SAR 256212 is a fully human anti ErbB3/HER3 antibody that blocks ligand-induced receptor activation. Formation of EGFR…
ErbB3 is a critical activator of phosphoinositide 3-kinase (PI3K) signaling in EGFR-, HER2-, and MET-addicted cancers, and ligand…
In women, breast cancer is among the most common cancers and the fifth most common cause of cancer deaths. Due to the…
3974 The role of the EGFR family in cancer is well documented. To date most of the attention has been focused on EGFR and ErbB2…