MLN4924
National Institutes of Health
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Protein neddylation is a post-translational modification by a covalent conjugation with the neural precursor cell expressed…
Immunohistochemistry-based biomarkers are commonly used to understand target inhibition in key cancer pathways in preclinical…
Abstract 578
MLN4924 is an investigational small molecule inhibitor of NEDD8-activating enzyme that has shown clinical activity…
MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from d-ribose via a route…
8529 Background: MLN4924 is an investigational inhibitor of NAE; NAE is an essential controller of the NEDD8 conjugation pathway…
Abstract 658 Background: NEDD8-activating enzyme (NAE) regulates the NEDD8 conjugation pathway, and is required for the activity…
Abstract 1854
Poster Board I-880
Background: MLN4924 is a first-in-class small molecule inhibitor of NEDD8-activating enzyme…
Successful therapeutic intervention in the ubiquitin-proteasome system (UPS) in multiple myeloma and mantle cell lymphoma with…