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MLN4924

National Institutes of Health

Papers overview

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2020
2020
Lipin-2 degradation elicits a proinflammatory gene signature in macrophages.
2018
2018
Inhibition of neddylation facilitates cell migration through enhanced phosphorylation of caveolin-1 in PC3 and U373MG cells
Protein neddylation is a post-translational modification by a covalent conjugation with the neural precursor cell expressed… 
2016
2016
HIV-1 Vpr increases HCV replication through VprBP in cell culture.
2014
2014
Applications of Pathology-Assisted Image Analysis of Immunohistochemistry-Based Biomarkers in Oncology
Immunohistochemistry-based biomarkers are commonly used to understand target inhibition in key cancer pathways in preclinical… 
2011
2011
Azacitidine/Decitabine Synergism with the NEDD8-Activating Enzyme Inhibitor MLN4924 in Pre-Clinical AML Models
Abstract 578 MLN4924 is an investigational small molecule inhibitor of NEDD8-activating enzyme that has shown clinical activity… 
2011
2011
Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme.
MLN4924 (1), which is in clinical trials as an anticancer agent, was stereoselectively synthesized from d-ribose via a route… 
2011
2011
MLN4924, an investigational NEDD8-activating enzyme (NAE) inhibitor, in patients (pts) with metastatic melanoma: Results of a phase I study.
8529 Background: MLN4924 is an investigational inhibitor of NAE; NAE is an essential controller of the NEDD8 conjugation pathway… 
2011
2011
Inhibition of NEDD 8-Activating Enzyme Induces Rereplication and Apoptosis in Human Tumor Cells Consistent with Deregulating CDT 1 Turnover
Loss of NEDD8-activating enzyme (NAE) function by siRNA knockdown or inhibition by the small molecule NAE inhibitor MLN4924 leads… 
2010
2010
The Novel, Investigational NEDD8-Activating Enzyme Inhibitor MLN4924 In Adult Patients with Acute Myeloid Leukemia (AML) or High-Grade Myelodysplastic Syndromes (MDS): A Phase 1 Study
Abstract 658 Background: NEDD8-activating enzyme (NAE) regulates the NEDD8 conjugation pathway, and is required for the activity… 
2009
2009
Phase 1 Dose-Escalation Study of MLN4924, a Novel NAE Inhibitor, in Patients with Multiple Myeloma and Non-Hodgkin Lymphoma.
Abstract 1854 Poster Board I-880 Background: MLN4924 is a first-in-class small molecule inhibitor of NEDD8-activating enzyme… 
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