MLN4924

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2009-2017
010203020092017

Papers overview

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2013
2013
MLN4924 is an investigational small-molecule inhibitor of the NEDD8-activating enzyme (NAE) in phase I clinical trials. NAE… (More)
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2013
2013
PURPOSE Ovarian cancer has the highest mortality rate of all female reproductive malignancies. Drug resistance is a major cause… (More)
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Highly Cited
2012
Highly Cited
2012
Posttranslational neddylation of cullins in the Cullin-Ring E3 ligase (CRL) complexes is needed for proteolytic degradation of… (More)
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Highly Cited
2012
Highly Cited
2012
Radiotherapy is used in locally advanced pancreatic cancers in which it can improve survival in combination with gemcitabine… (More)
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2011
2011
Cullin-RING ubiquitin ligases (CRLs) are responsible for the ubiquitination of many cellular proteins, thereby targeting them for… (More)
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2011
2011
Cullin-RING ubiquitin ligase (CRL), with its founding member of SKP1-Cullins-F-box proteins (SCF) E3 ubiquitin ligase, is the… (More)
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Highly Cited
2010
Highly Cited
2010
MLN4924 is a potent and selective small molecule NEDD8-activating enzyme (NAE) inhibitor. In most cancer cells tested, inhibition… (More)
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Highly Cited
2010
Highly Cited
2010
The NEDD8-activating enzyme (NAE) initiates a protein homeostatic pathway essential for cancer cell growth and survival. MLN4924… (More)
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Highly Cited
2010
Highly Cited
2010
MLN4924 is a first-in-class experimental cancer drug that inhibits the NEDD8-activating enzyme, thereby inhibiting cullin-RING E3… (More)
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Highly Cited
2009
Highly Cited
2009
The clinical development of an inhibitor of cellular proteasome function suggests that compounds targeting other components of… (More)
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