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MLN3897

National Institutes of Health

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2 relations

Broader (2)

BenzoxepinsPyridines

Papers overview

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2016
2016
Metabolism, Excretion and Pharmacokinetics of MLN3897, a CCR1 Antagonist, in Humans.
UNLABELLED MLN3897 is a small molecule antagonist of the C-C chemokine receptor-1. Since preclinical studies showed that the… 
2010
2010
Quantitative Prediction and Clinical Observation of a CYP3A Inhibitor-Based Drug-Drug Interactions with MLN3897, a Potent C-C Chemokine Receptor-1 Antagonist
A novel in vitro model was recently developed in our laboratories for the prediction of magnitude of clinical pharmacokinetic… 
2006
2006
MLN3897, a Novel CCR1 Antagonist, Inhibits Osteoclastogenesis by Blocking Early ERK Activation.
Osteolytic lesions are a hallmark of myeloma bone disease and other metastatic cancers, resulting in significant morbidity. In… 
2006
2006
CCR1 Inhibition Impairs Osteoclast Activity and Interaction with Myeloma Cells.
Multiple Myeloma (MM) is characterized by increased osteoclasts (OC) activity leading to severe bone disease. Several inducers of… 
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