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MLN3897 is a small molecule antagonist of the C-C chemokine receptor-1. Since preclinical studies showed that the… Expand The identification of chemokines and their receptors as potent mediators of leukocyte infiltration raised interest in the… Expand A novel in vitro model was recently developed in our laboratories for the prediction of magnitude of clinical pharmacokinetic… Expand OBJECTIVE
To assess the efficacy, safety, pharmacokinetics, and pharmacodynamics of the CC chemokine receptor CCR1 antagonist… Expand The interaction between osteoclasts (OCs) and multiple myeloma (MM) cells plays a key role in the pathogenesis of MM-related… Expand Osteolytic lesions are a hallmark of myeloma bone disease and other metastatic cancers, resulting in significant morbidity. In… Expand Multiple Myeloma (MM) is characterized by increased osteoclasts (OC) activity leading to severe bone disease. Several inducers of… Expand