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MKC-1

An orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites… Expand
National Institutes of Health

Papers overview

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2014
2014
Raf kinase inhibitor protein (RKIP) is a member of the phosphatidylethanolamine-binding-protein (PEBP) family that modulates the… Expand
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2011
2011
SummaryBackground MKC-1 is an orally available cell cycle inhibitor with downstream targets that include tubulin and the importin… Expand
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2010
2010
SummaryBackground MKC-1 is an oral cell-cycle inhibitor with broad antitumor activity in preclinical models. Clinical studies… Expand
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2010
2010
Bisindolylmaleimide MKC-1 (formerly known as Ro 31-7453) is a novel, orally active, small-molecule, cell cycle inhibitor with… Expand
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2009
2009
5577 Background: MKC-1 is a novel oral cell cycle inhibitor with preclinical activity in xenograft models of human ovarian and… Expand
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2009
2009
e19005 Background: MKC-1 is a novel oral cell cycle inhibitor with preclinical activity against NSCLC cell lines including multi… Expand
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2009
2009
AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO MKC-1 is a clinical-stage orally active cell-cycle inhibitor that exhibits… Expand
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2008
2008
1046 Background: MKC-1 is a novel oral cell cycle inhibitor with in vitro and in vivo activity against many tumor cell lines… Expand
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2007
2007
11508 Background: MKC-1 (previously Ro 31–7453) is a novel cell cycle inhibitor with significant in vitro and in vivo activity… Expand
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1999
1999
Keratin 14 (K14) is believed to play a pivotal role in the maintenance of epidermal cell shape and contributing to their… Expand
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