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MK-7246

 
National Institutes of Health

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2019
2019
INTRODUCTION MK-7246 is a potent and selective antagonist for chemoattractant receptor-homologous molecule expressed on Th2 cells… Expand
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2014
2014
Alternaria alternata is a fungal allergen linked to the development of severe asthma in humans. In view of the clinical… Expand
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2013
2013
Late phase airflow obstruction and reduction in forced vital capacity are characteristic features of human asthma. Airway… Expand
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2012
2012
MK-7246, an antagonist of the chemoattractant receptor on T helper type 2 (Th2) cells, is being developed for the treatment of… Expand
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2012
2012
In this paper, we report the development of different synthetic routes to MK-7246 (1) designed by the Process Chemistry group… Expand
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2011
2011
The chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) is a G protein-coupled receptor that… Expand
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2011
2011
In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies… Expand
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2011
2011
A new class of 7-azaindole analogs of MK-7246 as potent and selective CRTH2 antagonists is reported. The SAR leading to the… Expand
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