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MK-7246

 
National Institutes of Health

Papers overview

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2019
2019
INTRODUCTION MK-7246 is a potent and selective antagonist for chemoattractant receptor-homologous molecule expressed on Th2 cells… Expand
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2014
2014
Alternaria alternata is a fungal allergen linked to the development of severe asthma in humans. In view of the clinical… Expand
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2013
2013
Late phase airflow obstruction and reduction in forced vital capacity are characteristic features of human asthma. Airway… Expand
Highly Cited
2012
Highly Cited
2012
In this paper, we report the development of different synthetic routes to MK-7246 (1) designed by the Process Chemistry group… Expand
2012
2012
MK‐7246, an antagonist of the chemoattractant receptor on T helper type 2 (Th2) cells, is being developed for the treatment of… Expand
2011
2011
The chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) is a G protein-coupled receptor that… Expand
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2011
2011
In this manuscript we wish to report the discovery of MK-7246 (4), a potent and selective CRTH2 (DP2) antagonist. SAR studies… Expand
2011
2011
A new class of 7-azaindole analogs of MK-7246 as potent and selective CRTH2 antagonists is reported. The SAR leading to the… Expand
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