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MK 436

Known as: MK 0436, MK-0436, MK-436 
National Institutes of Health

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1 relation

Broader (1)

Nitroimidazoles

Papers overview

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Review
2016
Review
2016
Stairway to Heaven or Hell? Perspectives and Limitations of Chagas Disease Chemotherapy.
In this review, we intend to provide a general view of the evolution of experimental studies in the area of chemotherapy for… 
1998
1998
A method to assess invasion and intracellular replication of Trypanosoma cruzi based on differential uracil incorporation.
  • W. YanS. Moreno
  • JIM - Journal of Immunological Methods
  • 1998
  • Corpus ID: 34576669
1996
1996
Topical chemotherapy for experimental murine African CNS‐trypanosomiasis: the successful use of the arsenical, melarsoprol, combined with the 5‐nitroimidazoles, fexinidazole or MK‐436
The 5‐nitroimidazoles, MK‐436 and fexinidazole dissolved in dimethylsulphoxide can be converted by the addition of… 
Highly Cited
1991
Highly Cited
1991
Reversibility of cardiac fibrosis in mice chronically infected with Trypanosoma cruzi, under specific chemotherapy.
UNLABELLED This investigation was performed to verify the effect of specific chemotherapy (Benznidazole or MK-436) on the… 
1991
1991
Chemotherapy of CNS-trypanosomiasis: combination chemotherapy with a 5-nitroimidazole (MK 436), an arsenical (Cymelarsan) and suramin.
A detailed study of the combined effect of suramin, MK 436 (5-nitroimidazole) and Cymelarsan (melaminylthioarsenate) was… 
1989
1989
Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole.
The antiprotozoal drug 3-(1-methyl-5-nitroimidazol-2-yl)-3a, 4,5,6,7,7a-hexahydro-1,2-benzisoxazole (MK-436) is highly… 
1987
1987
Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study.
The anti-protozoal drug MK-436 (3-(1-methyl-5-nitroimidazol-2-yl)-3a,4,5,6,7,7a-hexahydro-1,2-benzisoxazole) was found to be… 
1984
1984
Effect of liver enzymes on the mutagenicity of nitroheterocyclic compounds: activation of 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)- 1,2-benzisoxazole and deactivation of…
1983
1983
Identification of in vitro (rat liver postmitochondrial S9 fraction) metabolites of the antiprotozoal agent 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole .
Twelve in vitro oxygenated metabolites of 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole (MK… 
1980
1980
Identification of canine urinary metabolites of the antiprotozoal agent 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole .
Metabolite fractions from the urine of a dog dosed with 3a,4,5,6,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2… 
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