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MK-0777

 
National Institutes of Health

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Highly Cited
2011
Highly Cited
2011
A Randomized Clinical Trial of MK-0777 for the Treatment of Cognitive Impairments in People with Schizophrenia
BACKGROUND In a previous pilot study, MK-0777--a γ-aminobutyric acid (GABA)(A) α2/α3 partial agonist--was reported to improve… Expand
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2011
2011
Pharmacological Enhancement of Cognition in Individuals with Schizophrenia
w n “ i fi a f n d c t o t t T he principal pharmacological treatment for schizophrenia, antipsychotic medications, reduces the… Expand
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Review
2011
Review
2011
GABA Neuron Alterations, Cortical Circuit Dysfunction and Cognitive Deficits in Schizophrenia
Schizophrenia is a brain disorder associated with cognitive deficits that severely affect the patients' capacity for daily… Expand
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2010
2010
Benzodiazepine binding site occupancy by the novel GABAA receptor subtype-selective drug 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b…
The GABA(A) receptor alpha2/alpha3 subtype-selective compound 7-(1,1-dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2… Expand
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Highly Cited
2008
Highly Cited
2008
Subunit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia.
OBJECTIVE Deficits in working memory and cognitive control in schizophrenia are associated with impairments in prefrontal… Expand
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