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MJ 33

Known as: MJ-33, MJ33 
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
The phospholipase A2 activity of peroxiredoxin 6[S]
Peroxiredoxin 6 (Prdx6) is a Ca2+-independent intracellular phospholipase A2 (called aiPLA2) that is localized to cytosol… 
Review
2017
Review
2017
Targeting therapeutics to endothelium: are we there yet?
Vascular endothelial cells represent an important therapeutic target in many pathologies, including inflammation, oxidative… 
Highly Cited
2016
Highly Cited
2016
Peroxiredoxins prevent oxidative stress during human sperm capacitation
STUDY QUESTION Do peroxiredoxins (PRDXs) control reactive oxygen species (ROS) levels during human sperm capacitation? SUMMARY… 
2013
2013
A Novel Nontoxic Inhibitor of the Activation of NADPH Oxidase Reduces Reactive Oxygen Species Production in Mouse Lung
1-Hexadecyl-3-trifluoroethylglycero-sn-2-phosphomethanol (MJ33) is a fluorinated phospholipid analog that inhibits the… 
2012
2012
The roles of peroxidase and phospholipase A2 activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress.
AIMS Peroxiredoxin 6 (Prdx6), a bifunctional enzyme with glutathione peroxidase and phospholipase A(2) (PLA(2)) activities, has… 
2006
2006
Lung phospholipid metabolism in transgenic mice overexpressing peroxiredoxin 6.
Highly Cited
2002
Highly Cited
2002
Polycyclic aromatic hydrocarbons present in cigarette smoke cause endothelial cell apoptosis by a phospholipase A2dependent mechanism
Smoking is a major risk factor for endothelial cell injury and subsequent coronary artery disease. Epidemiological studies… 
Highly Cited
2001
Highly Cited
2001
Five coplanar anion binding sites on one face of phospholipase A2: relationship to interface binding.
We report the structures of the crystallographic dimer of porcine pancreatic IB phospholipase A(2) (PLA2) with either five… 
1997
1997
Crystal structure of the complex of bovine pancreatic phospholipase A2 with the inhibitor 1-hexadecyl-3-(trifluoroethyl)-sn-glycero-2-phosphomethanol,.
The structure of recombinant bovine pancreatic phospholipase A2 (PLA2) complexed with the competitive inhibitor 1-hexadecyl-3… 
Highly Cited
1991
Highly Cited
1991
Active-site-directed specific competitive inhibitors of phospholipase A2: novel transition-state analogues.
More than 100 amphiphilic phosphoesters, possible tetrahedral transition-state analogues capable of coordinating to the calcium… 
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