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Treatment of advanced BRAF V600 -mutant melanoma using BRAF inhibitors (BRAFi) eventually leads to drug resistance and selects… Expand Early studies have provided a wealth of information on the functions of microRNAs (miRNAs). However, less is known regarding… Expand Thyroid-carcinoma (THCA) is the most common malignancy with an increasing incidence. Recent evidence has emphasized the role of… Expand Hepatic insulin resistance, defined as a diminished ability of hepatocytes to respond to the action of insulin, plays an… Expand BackgroundEpigenetics has been investigated in cancer initiation, and development, especially, since the appearance of… Expand Cisplatin is commonly used in ovarian cancer treatment by inducing apoptosis in cancer cells as a result of lethal DNA damage… Expand Purpose The (pro)renin receptor (PRR), a component of the renin-angiotensin system (RAS), plays an important role in the… Expand Parent-of-origin imprints have been implicated in the regulation of neural differentiation and brain development. Previously we… Expand Nickel (Ni) compounds are well-recognized human carcinogens, yet the molecular mechanisms by which they cause human cancer are… Expand MicroRNAs (MIRs) perform critical regulatory functions within cell networks, both in physiology as well as in pathology. Through… Expand