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MHY1485

 
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
Increased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons.
Neuronal inflammation is the characteristic pathologic change of acute neurologic impairment and chronic traumatic encephalopathy… Expand
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2018
2018
Hyperglycemia‐induced Bcl‐2/Bax‐mediated apoptosis of Schwann cells via mTORC1/S6K1 inhibition in diabetic peripheral neuropathy
ABSTRACT Schwann cell apoptosis is one of the characteristics of diabetic peripheral neuropathy (DPN). The mammalian target of… Expand
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2017
2017
MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling
Ultra Violet (UV)-caused skin cell damage is a main cause of skin cancer. Here, we studied the activity of MHY1485, a mTOR… Expand
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2017
2017
Administration of follicle-stimulating hormone induces autophagy via upregulation of HIF-1α in mouse granulosa cells
Recent studies reported the important role of autophagy in follicular development. However, the underlying molecular mechanisms… Expand
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2017
2017
Salidroside attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation and apoptosis resistance by upregulating autophagy through the AMPK-mTOR-ULK1 pathway
BackgroundRecent studies have shown that both adenosine monophosphate activated protein kinase (AMPK) and the mammalian target of… Expand
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2017
2017
Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation
Psoriasis is a frequent and often severe inflammatory skin disease, characterized by altered epidermal homeostasis. Since we… Expand
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2017
2017
AMPK-autophagy inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity
The current research studied the potential effect of autophagy on icaritin-induced anti-colorectal cancer (CRC) cell activity… Expand
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2016
2016
MHY1485 activates mTOR and protects osteoblasts from dexamethasone.
Dexamethasone (Dex) exerts cytotoxic effects to cultured osteoblasts. The potential effect of MHY1485, a small-molecular… Expand
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2015
2015
Promotion of Ovarian Follicle Growth following mTOR Activation: Synergistic Effects of AKT Stimulators
Mammalian target of rapamycin (mTOR) is a serine/threonine kinase and mTOR signaling is important in regulating cell growth and… Expand
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Highly Cited
2012
Highly Cited
2012
Inhibitory Effect of mTOR Activator MHY1485 on Autophagy: Suppression of Lysosomal Fusion
Autophagy is a major degradative process responsible for the disposal of cytoplasmic proteins and dysfunctional organelles via… Expand
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