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MGI-114

Known as: MGI 114, MGI.114 
National Institutes of Health

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Broader (1)

irofulven

Papers overview

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Highly Cited
2004
Highly Cited
2004
The cercus-to-giant interneuron system of crickets
Summary1.The anatomical and physiological characteristics of filiform hairs, receptor elements on the cerci of the cricketAcheta… 
2004
2004
Efficacy of HMAF (MGI-114) in the MV522 metastatic lung carcinoma xenograft model nonresponsive to traditional anticancer agents
SummaryIlludin analogs are cytotoxic to a variety of multidrug resistant cell lines, and display an unusual toxicity towards DNA… 
2004
2004
The cercus-to-giant interneuron system of crickets
Summary1.The pattern of connections between cereal sensory neurons and a single sensory interneuron, the medial giant interneuron… 
2004
2004
Evaluation of irofulven (MGI-114) in the treatment of recurrent or persistent endometrial carcinoma: A phase II study of the Gynecologic Oncology Group
Objective: This multi-center phase II trial was conducted by the Gynecologic Oncology Group to evaluate the activity and toxicity… 
2002
2002
A Phase II Study of Irofulven (MGI 114) in Patients with Stage IV Melanoma
Sixteen patients with stage IV melanoma,who were heavily pretreated, received11 mg/m2/day of intravenous Irofulvenfor five… 
2000
2000
Efficacy of MGI 114 (HMAF) against the MRP+ metastatic MV522 lung carcinoma xenograft
This study is part of an effort to evaluate efficacy of the novel agent MGI 114 (HMAF) against tumors resistant to conventional… 
2000
2000
Enhanced antitumour activity of 6-hydroxymethylacylfulvene in combination with topotecan or paclitaxel in the MV522 lung carcinoma xenograft model.
2000
2000
Anti-leukemic action of the novel agent MGI 114 (HMAF) and synergistic action with topotecan
The illudin derivative MGI 114 (6-hydroxymethylacylfulvene or HMAF) is currently in phase II chemotherapeutic clinical trials for… 
2000
2000
MGI 114: augmentation of antitumor activity when combined with topotecan.
PURPOSE 6-Hydroxymethylacylfulvene (HMAF; MGI 114; Irofulven) is a semisynthetic analogue of the mushroom toxin illudin S that… 
1999
1999
Cytotoxic effects of MGI 114 are independent of tumor p53 or p21 expression.
MGI 114, an analog of illudin S, shows potent activity against a broad range of human tumors in vitro and in vivo, including drug… 
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