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Estrogen and estrogen receptors (ERα and ERβ) play an important role in breast cancer. Currently, antiestrogen (AE) targeted to… Expand Introduction: The Women's Health Initiative Estrogen Plus Progestin clinical trial demonstrated the risks exceeded the benefits… Expand Objective To evaluate the level of reduction in hot flushes among a cohort of postmenopausal women randomized to a phase-2… Expand Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL
Aromatase inhibitors (AI) have shown efficacy against… Expand Estrogens are used extensively to treat hot flashes in menopausal women. Some of the beneficial effects of estrogens in hormone… Expand Estrogens produce biological effects by interacting with two estrogen receptors, ERα and ERβ. Drugs that selectively target ER… Expand Objective: In randomized trials, the most common way to measure the effect of treatment on the frequency and severity of… Expand After the Women's Health Initiative found that the risks of hormone therapy outweighed the benefits, a need for alternative drugs… Expand Liquiritigenin [2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-(S)-4H-1-benzopyran-4-one] is one of the major active compounds of… Expand Novel estrogenic therapies are needed that ameliorate menopausal symptoms and have the bone-sparing effects of endogenous… Expand