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MF101

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Abstract 1312: The estrogen receptor β agonists, Liquiritigenin and S-equol, inhibit breast cancer cell proliferation through the activation of tumor-suppressor and other pathways.
Estrogen and estrogen receptors (ERα and ERβ) play an important role in breast cancer. Currently, antiestrogen (AE) targeted to… 
Review
2012
Review
2012
MF101: a multi-component botanical selective estrogen receptor beta modulator for the treatment of menopausal vasomotor symptoms
Introduction: The Women's Health Initiative Estrogen Plus Progestin clinical trial demonstrated the risks exceeded the benefits… 
2012
2012
Clinically meaningful efficacy of a non-estrogen agent: re-analysis of phase-2 data evaluating MF101
Objective To evaluate the level of reduction in hot flushes among a cohort of postmenopausal women randomized to a phase-2… 
2011
2011
Liquiritigenin Attenuates Alzheimer’s-Like Neuropathology in an Amyloid Protein Precursor Transgenic Mouse Model and the Underlying Mechanisms
Estrogen plays a key regulatory role in a number of biological processes and, in addition to its classic function as a sex… 
2010
2010
Estrogen Receptor β-Selective Agonists Stimulate Calcium Oscillations in Human and Mouse Embryonic Stem Cell-Derived Neurons
Estrogens are used extensively to treat hot flashes in menopausal women. Some of the beneficial effects of estrogens in hormone… 
Highly Cited
2009
Highly Cited
2009
Drug and Cell Type-Specific Regulation of Genes with Different Classes of Estrogen Receptor β-Selective Agonists
Estrogens produce biological effects by interacting with two estrogen receptors, ERα and ERβ. Drugs that selectively target ER… 
2009
2009
Is a shorter hot flash diary just as good as a 7-day diary?
Objective: In randomized trials, the most common way to measure the effect of treatment on the frequency and severity of… 
Highly Cited
2008
Highly Cited
2008
Liquiritigenin is a plant-derived highly selective estrogen receptor β agonist
2008
2008
Oxidative in Vitro Metabolism of Liquiritigenin, a Bioactive Compound Isolated from the Chinese Herbal Selective Estrogen β-Receptor Agonist MF101
Liquiritigenin [2,3-dihydro-7-hydroxy-2-(4-hydroxyphenyl)-(S)-4H-1-benzopyran-4-one] is one of the major active compounds of… 
Review
2001
Review
2001
Phase I/II Pilot Study to Assess Toxicity and Efficacy of Chinese Herbs to Treat Hot Flashed and Menopausal Symptoms for Women With a History of Breast Cancer
Abstract : The goal of the study is to assess the safety and feasibility of a Chinese herbal formula, MF101, in alleviating hot… 
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