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MED8 gene

Known as: MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 8, S. CEREVISIAE, HOMOLOG OF, MGC17544, ARC32 
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
PFT1, a transcriptional Mediator complex subunit, controls root hair differentiation through reactive oxygen species (ROS) distribution in Arabidopsis.
Root hair morphogenesis is driven by an amalgam of interacting processes controlled by complex signaling events. Redox processes… 
Highly Cited
2012
Highly Cited
2012
Structure of the Mediator head module
Gene transcription by RNA polymerase (Pol) II requires the coactivator complex Mediator. Mediator connects transcriptional… 
2009
2009
The Med8 mediator subunit interacts with the Rpb4 subunit of RNA polymerase II and Ace2 transcriptional activator in Schizosaccharomyces pombe
Highly Cited
2006
Highly Cited
2006
Structure and TBP binding of the Mediator head subcomplex Med8–Med18–Med20
The Mediator head module stimulates basal RNA polymerase II (Pol II) transcription and enables transcriptional regulation. Here… 
Highly Cited
2003
Highly Cited
2003
Identification of Mammalian Mediator Subunits with Similarities to Yeast Mediator Subunits Srb5, Srb6, Med11, and Rox3* 210
The Mediator is a multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding… 
2003
2003
Functional Interactions within Yeast Mediator and Evidence of Differential Subunit Modifications*
It is possible to recruit RNA polymerase II to a target promoter and, thus, activate transcription by fusing Mediator subunits to… 
Highly Cited
2002
Highly Cited
2002
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase
The heterodimeric Elongin BC complex has been shown to interact in vitro and in cells with a conserved BC-box motif found in an… 
2002
2002
Mediator factor Med8p interacts with the hexokinase 2: implication in the glucose signalling pathway of Saccharomyces cerevisiae.
Highly Cited
2001
Highly Cited
2001
Analysis of Schizosaccharomyces pombe Mediator reveals a set of essential subunits conserved between yeast and metazoan cells
With the identification of eight new polypeptides, we here complete the subunit characterization of the Schizosaccharomyces pombe… 
1999
1999
Med8, a subunit of the mediator CTD complex of RNA polymerase II, directly binds to regulatory elements of SUC2 and HXK2 genes.
In a search to identify new factors required for expression of SUC2 gene in Saccharomyces cerevisiae, we have partially purified… 
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