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MECP2 wt Allele

Known as: MECP2, Methyl CpG Binding Protein 2 (Rett Syndrome) wt Allele 
Human MECP2 wild-type allele is located in the vicinity of Xq28 and is approximately 76 kb in length. This allele, which encodes methyl-CpG-binding… 
National Institutes of Health

Related topics

Related topics

7 relations
DNA Methylation RegulationHomo sapiensMethyl-CpG-Binding Protein 2Rett Syndrome

Broader (1)

MECP2 gene

Papers overview

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2019
2019
Behavioral Characterization of MeCP2 Dysfunction-Associated Rett Syndrome and Neuropsychiatric Disorders.
The methyl-CpG-binding protein 2 (MECP2) gene has been implicated in multiple neuropsychiatric disorders such as autism and… 
2018
2018
Disorders of the Nervous System Activation of the Medial Prefrontal Cortex Reverses Cognitive and Respiratory Symptoms in a Mouse Model of Rett Syndrome
Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by loss-of-function mutations in the gene encoding methyl-CpG… 
2017
2017
MeCP2 mediated dysfunction in senescent EPCs
Aging endothelial progenitor cells (EPCs) exhibit functional impairment in terms of proliferation, migration and survival. SIRT1… 
2016
2016
LACK OF Mecp 2 INTERFERES WITH CORTICAL PROGENITORS PROLIFERATION AND DIFFERENTIATION
Rett syndrome (RTT) is a progressive neurological disorder affecting 1 in 10.000 live female births; nowadays is the most common… 
2016
2016
MECP2 Duplications in Symptomatic Females
Xq28 microduplications including the MECP2 gene constitute a 100% penetrant X-linked syndrome in males caused by overexpression… 
2015
2015
Methyl CpG Binding Protein 2 Gene Disruption Augments Tonic Currents of γ-Aminobutyric Acid Receptors in Locus Coeruleus Neurons
Background: Mecp2 disruption causes hyperexcitability of locus coeruleus (LC) neurons with autonomic dysfunction. Results… 
2015
2015
Mitigating False‐Positive Associations in Rare Disease Gene Discovery
Clinical sequencing is expanding, but causal variants are still not identified in the majority of cases. These unsolved cases can… 
2012
2012
Altered microtubule dynamics in Mecp2‐deficient astrocytes
Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by mutations in the gene MECP2 encoding the methyl‐CpG binding… 
2011
2011
Setdb1-mediated histone H3K9 hypermethylation in neurons worsens the neurological phenotype of Mecp2-deficient mice
2005
2005
Lost in translation: translational interference from a recurrent mutation in exon 1 of MECP2
Background: Rett syndrome (RTT) is an X linked neuro-developmental disorder affecting mostly girls. Mutations in the coding… 
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