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MCM8 gene

Known as: dJ967N21.5, MCM8, MGC119522 
 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Exome sequencing reveals MCM8 mutation underlies ovarian failure and chromosomal instability.
Premature ovarian failure (POF) is a genetically and phenotypically heterogeneous disorder that includes individuals with… Expand
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Highly Cited
2015
Highly Cited
2015
Minichromosome maintenance complex component 8 (MCM8) gene mutations result in primary gonadal failure
Background Primary gonadal failure is characterised by primary amenorrhoea or early menopause in females, and oligospermia or… Expand
2015
2015
MCM8-9 complex promotes resection of double-strand break ends by MRE11-RAD50-NBS1 complex
MCM8-9 complex is required for homologous recombination (HR)-mediated repair of double-strand breaks (DSBs). Here we report that… Expand
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Highly Cited
2013
Highly Cited
2013
The MCM8-MCM9 Complex Promotes RAD51 Recruitment at DNA Damage Sites To Facilitate Homologous Recombination
ABSTRACT The minichromosome maintenance protein homologs MCM8 and MCM9 have previously been implicated in DNA replication… Expand
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Highly Cited
2012
Highly Cited
2012
MCM8- and MCM9-deficient mice reveal gametogenesis defects and genome instability due to impaired homologous recombination.
We generated knockout mice for MCM8 and MCM9 and show that deficiency for these genes impairs homologous recombination (HR… Expand
Highly Cited
2007
Highly Cited
2007
Genome-Wide Analysis of the Core DNA Replication Machinery in the Higher Plants Arabidopsis and Rice1[W][OA]
Core DNA replication proteins mediate the initiation, elongation, and Okazaki fragment maturation functions of DNA replication… Expand
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Highly Cited
2005
Highly Cited
2005
REC, Drosophila MCM8, Drives Formation of Meiotic Crossovers
Crossovers ensure the accurate segregation of homologous chromosomes from one another during meiosis. Here, we describe the… Expand
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Highly Cited
2005
Highly Cited
2005
MCM8 Is an MCM2-7-Related Protein that Functions as a DNA Helicase during Replication Elongation and Not Initiation
MCM2-7 proteins are replication factors required to initiate DNA synthesis and are currently the best candidates for replicative… Expand
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Highly Cited
2005
Highly Cited
2005
Involvement of Human MCM8 in Prereplication Complex Assembly by Recruiting hcdc6 to Chromatin
ABSTRACT The MCM2-MCM7 complex is an essential component of the prereplication complex (pre-RC), which is recruited by the cdc6… Expand
Highly Cited
2002
Highly Cited
2002
Evaluation of the immunocontraceptive potential of Escherichia coli-expressed recombinant dog ZP2 and ZP3 in a homologous animal model.
Dog zona pellucida glycoprotein 2 (dZP2), excluding the N-terminal signal sequence and the C-terminal transmembrane-like domain… Expand
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