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MCL-1 Inhibitor AMG 176

Known as: AMG 176 
An inhibitor of induced myeloid leukemia cell differentiation protein MCL-1 (myeloid cell leukemia-1), with potential pro-apoptotic and… 
National Institutes of Health

Papers overview

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2018
2018
抑制 Mcl-1 表达调控结核感染的小鼠腹腔巨噬细胞凋亡的机制初探
2018
2018
Abstract 3972: Combined inhibition of MCL1 and BCL-2 with AMG 176 and venetoclax induces anti-tumor effects in primary patient samples and models of acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous hematological malignancy involving the clonal expansion of immature myeloid cells… 
2018
2018
Abstract 880: Anti-tubulin antibody drug conjugates potentiate venetoclax activity in non-Hodgkin lymphoma by targeting MCL-1
Venetoclax, a potent, orally bioavailable inhibitor that selectively targets BCL-2 and induces intrinsic apoptosis, is currently… 
2017
2017
Abstract DDT01-01: The discovery and preclinical characterization of AMG 176: A first-in-class Mcl-1 inhibitor in clinical development for multiple myeloma
Mcl-1 is a prosurvival member of the Bcl-2 family of proteins, which regulate programmed cell death via protein-protein… 
2016
2016
MCL-1 siRNA Reverses the Chemoresistance of Cisplatin-resistant SW 480 Cells via the Pathway of Mitochondrial Apoptosis
OBJECTIVE To investigate the relationship between the expression of MCL-1 and the cisplatin-resistance in cisplatin-resistant… 
2015
2015
靶向沉默 Mcl-1 基因对感染不同毒力结核杆菌小鼠腹腔巨噬细胞凋亡的影响
2014
2014
Regulation of intestinal epithelial apoptosis by protease‐activated receptor 2 involves EGFR‐transactivation and is associated with Mcl‐1 upregualtion (151.1)
Colonic biopsies from inflamed colon have higher levels of epithelial apoptosis than biopsies from healthy individuals. Therapies… 
2008
2008
Mimetic Obatoclax Enhances TRAIL-Mediated Apoptosis in Human Pancreatic Cancer Cells
Purpose: Prosurvival Bcl-2 proteins inhibit the mitochondrial and death receptor-mediated apoptotic pathways. Obatoclax is a… 
2004
2004
Hepatocyte growth factor-activated NFk B regulates HIF-1 activity and ODC expression , implicated in survival , differently in different carcinoma cell lines
Hepatocyte growth factor (HGF)-stimulated Met signaling influences tumor survival, growth and progression, all processes… 
2003
2003
O-257 Mcl-1 is a survival factor in lung cancer
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