MB21D1 protein, human

Known as: cGAS protein, human, MB21D1, EC 2.7.7.- 
Cyclic GMP-AMP synthase (522 aa, ~59 kDa) is encoded by the human MB21D1 gene. This protein plays a role both cyclic dinucleotide synthesis and… (More)
National Institutes of Health

Papers overview

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2016
2016
The neuroinflammatory autoimmune disease Aicardi-Goutières syndrome (AGS) develops from mutations in genes encoding several… (More)
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2014
Highly Cited
2014
The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes… (More)
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Highly Cited
2014
Highly Cited
2014
The presence of DNA in the cytoplasm is a danger signal that triggers immune and inflammatory responses. Cytosolic DNA binds to… (More)
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2014
2014
Cytosolic detection of DNA is crucial for the initiation of antiviral immunity but can also cause autoimmunity in the context of… (More)
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2013
Highly Cited
2013
The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers host immune responses such as the… (More)
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2013
Highly Cited
2013
The presence of foreign DNA in the cytosol of mammalian cells elicits a potent antiviral interferon response. Recently, cytosolic… (More)
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2007
Highly Cited
2007
We present prevalence data for adolescents in a large metropolitan area in the US and the association of DSM-IV diagnoses to… (More)
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2003
2003
OBJECTIVE To study rates and ages of onset of DSM-IV syndromal and subsyndromal comorbidity in a prepubertal and early adolescent… (More)
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2001
Highly Cited
2001
To improve understanding of the factors affecting pesticide occurrence in ground water, patterns of detection were examined for… (More)
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Highly Cited
1995
Highly Cited
1995
Four studies on the inter-rater reliability of a proposed Axis V version for DSM-IV and of the CGAS involving 162 child and… (More)
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