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MAPK10 wt Allele

Known as: JNK3A, PRKM10, FLJ12099 
Human MAPK10 wild-type allele is located within 4q22.1-q23 and is approximately 344 kb in length. This allele, which encodes mitogen-activated… 
National Institutes of Health

Related topics

Related topics

19 relations
4q22.1-q23Adipocytokine Signaling PathwayCell Cycle ControlCell Proliferation

Broader (1)

MAPK10 gene

Papers overview

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Review
2011
Review
2011
JNK3 as a therapeutic target for neurodegenerative diseases.
c-Jun N-terminal kinases (JNKs) and in particular JNK3 the neuronal specific isoform, have been recognized as important enzymes… 
Highly Cited
2010
Highly Cited
2010
p75 Neurotrophin Receptor-mediated Apoptosis in Sympathetic Neurons Involves a Biphasic Activation of JNK and Up-regulation of Tumor Necrosis Factor-α-converting Enzyme/ADAM17*
During the development of the sympathetic nervous system, the p75 neurotrophin receptor (p75NTR) has a dual function: promoting… 
Highly Cited
2005
Highly Cited
2005
Physiological Regulation of the β-Amyloid Precursor Protein Signaling Domain by c-Jun N-Terminal Kinase JNK3 during Neuronal Differentiation
β-Amyloid precursor protein (APP) is a conserved and ubiquitous transmembrane glycoprotein strongly implicated in the… 
Review
2004
Review
2004
Targeting JNK3 for the treatment of neurodegenerative disorders.
Highly Cited
2003
Highly Cited
2003
The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity.
2002
2002
JNK3 contributes to c‐jun induction and apoptosis in 4‐hydroxynonenal‐treated sympathetic neurons
4‐Hydroxynoneal (HNE), an end product of lipid peroxidation, induces apoptosis in many cell types, including neural cells. HNE… 
Highly Cited
2001
Highly Cited
2001
Arsenic induces apoptosis in rat cerebellar neurons via activation of JNK3 and p38 MAP kinases.
Primary cultures of rat cerebellar neurons were used to study mechanisms of arsenic neurotoxicity. Exposure to 5, 10, or 15… 
Highly Cited
2001
Highly Cited
2001
Identification of a Motif in the Carboxyl Terminus of β-Arrestin2 Responsible for Activation of JNK3*
Accumulating evidence indicates that the β-arrestins act as scaffold molecules that couple G-protein-coupled receptors to mitogen… 
Highly Cited
1998
Highly Cited
1998
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis.
Highly Cited
1997
Highly Cited
1997
JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases
The function of the tumor suppressor protein p53 is modulated by post-translational events, primarily by phosphorylation. p53 is… 
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