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MAPK10 wt Allele

Known as: JNK3A, PRKM10, FLJ12099 
Human MAPK10 wild-type allele is located within 4q22.1-q23 and is approximately 344 kb in length. This allele, which encodes mitogen-activated… 
National Institutes of Health

Related topics

Related topics

19 relations
4q22.1-q23Adipocytokine Signaling PathwayCell Cycle ControlCell Proliferation
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Broader (1)

MAPK10 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
c-Jun N-terminal Kinase (JNK) Signaling as a Therapeutic Target for Alzheimer’s Disease
c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in stress signaling pathways implicated… 
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Highly Cited
2012
Highly Cited
2012
JNK3 Perpetuates Metabolic Stress Induced by Aβ Peptides
Although Aβ peptides are causative agents in Alzheimer's disease (AD), the underlying mechanisms are still elusive. We report… 
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Highly Cited
2009
Highly Cited
2009
Pathogenic Huntingtin Inhibits Fast Axonal Transport by Activating JNK3 and Phosphorylating Kinesin
Selected vulnerability of neurons in Huntington's disease suggests that alterations occur in a cellular process that is… 
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Highly Cited
2005
Highly Cited
2005
Specific pathophysiological functions of JNK isoforms in the brain
We have investigated the effect of JNK1 ko, JNK2 ko, JNK3 ko, JNK2+3 ko and c‐JunAA mutation on neuronal survival in adult… 
Highly Cited
2005
Highly Cited
2005
c‐Jun N‐terminal kinases (JNKs) mediate pro‐inflammatory actions of microglia
The activation and function of c‐Jun N‐terminal kinases (JNKs) were investigated in primary microglia cultures from neonatal rat… 
Highly Cited
2003
Highly Cited
2003
A critical role of neural-specific JNK3 for ischemic apoptosis
c-Jun N-terminal kinase (JNK) signaling is an important contributor to stress-induced apoptosis, but it is unclear whether JNK… 
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Highly Cited
2003
Highly Cited
2003
The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity.
The c-Jun terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family and regulate signal… 
Highly Cited
2000
Highly Cited
2000
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
beta-Arrestins, originally discovered in the context of heterotrimeric guanine nucleotide binding protein-coupled receptor (GPCR… 
Highly Cited
1998
Highly Cited
1998
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis.
BACKGROUND The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein (MAP) kinase family, and regulate… 
Highly Cited
1995
Highly Cited
1995
p493F12 kinase: A novel MAP kinase expressed in a subset of neurons in the human nervous system
Monoclonal antibody 3F12 identifies a cytoplasmic antigen of 49 kDa in human hippocampus and neocortex. The distribution of 3F12… 
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