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MAP3K2 gene

Known as: MAP/ERK KINASE KINASE 2, MAP3K2, MEKK2 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
MicroRNA-335 inhibits the growth, chemo-sensitivity, and metastasis of human breast cancer cells by targeting MAP3K2.
PURPOSE Molecular mechanism of breast cancer (BC) is relatively unknown and its metastasis is highly complicated. In this context… 
2018
2018
Discovery and characterization of an iminocoumarin scaffold as an inhibitor of MEKK2 (MAP3K2).
2015
2015
MAPK Genes Interact with Diet and Lifestyle Factors to Alter Risk of Breast Cancer: The Breast Cancer Health Disparities Study
Mitogen-activated protein kinases (MAPK) are integration points for multiple biochemical signals. We evaluated 13 MAPK genes with… 
2015
2015
Interaction with the Paxillin LD1 Motif Relieves MEKK2 Auto-inhibition
The cell signaling molecule MEK kinase 2 (MEKK2) is a key upstream regulator of MAPK activity that regulates numerous cellular… 
2014
2014
MEKK2 regulates paxillin ubiquitylation and localization in MDA-MB 231 breast cancer cells.
The intracellular kinase MEKK2 (mitogen-activated protein kinase/extracellular-signal-regulated kinase kinase kinase 2) is an… 
Highly Cited
2012
Highly Cited
2012
MicroRNA-520b Inhibits Growth of Hepatoma Cells by Targeting MEKK2 and Cyclin D1
Growing evidence indicates that the deregulation of microRNAs (miRNAs) contributes to the tumorigenesis. We previously revealed… 
2010
2010
Calcium Regulation of EGF-Induced ERK5 Activation: Role of Lad1-MEKK2 Interaction
The ERK5 cascade is a MAPK pathway that transmits both mitogenic and stress signals, yet its mechanism of activation is not fully… 
Highly Cited
2009
Highly Cited
2009
NF-κB-Dependent Induction of Cathelicidin-Related Antimicrobial Peptide in Murine Mast Cells by Lipopolysaccharide
Background: An important aspect of the innate immune response to pathogens is the production of anti-microbial peptides such as… 
2005
2005
A Novel Mitogen-Activated Protein Kinase Docking Site in the N Terminus of MEK5α Organizes the Components of the Extracellular Signal-Regulated Kinase 5 Signaling Pathway
ABSTRACT The alternative splicing of the mek5 gene gives rise to two isoforms. MEK5β lacks an extended N terminus present in MEK5… 
2005
2005
Protein kinase C alpha, betaI, and betaII isozymes regulate cytokine production in mast cells through MEKK2/ERK5-dependent and -independent pathways.
Regulation of MAPK pathways by PKC isoforms was examined in murine bone marrow-derived mast cells (BMMCs). The PKCalpha, betaI… 
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