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MAP2K5 gene

Known as: MAP2K5, MEK5, MAPKK5 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
MEK5/ERK5 Signaling Suppresses Estrogen Receptor Expression and Promotes Hormone-Independent Tumorigenesis
Endocrine resistance and metastatic progression are primary causes of treatment failure in breast cancer. While mitogen activated… 
2010
2010
ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy
Diabetic retinopathy is one of the most common causes of blindness in North America. Several signaling mechanisms are activated… 
2010
2010
Gαq Acts as an Adaptor Protein in Protein Kinase Cζ (PKCζ)-mediated ERK5 Activation by G Protein-coupled Receptors (GPCR)*♦
Gq-coupled G protein-coupled receptors (GPCR) mediate the actions of a variety of messengers that are key regulators of different… 
2007
2007
Aberrant Extracellular Signal-Regulated Kinase (ERK) 5 Signaling in Hippocampus of Suicide Subjects
Extracellular signal-regulated kinase 5 (ERK5), the newest member of the mitogen-activated protein (MAP) kinase family, is… 
Highly Cited
2006
Highly Cited
2006
Protein Kinase-mediated Regulation of Calcineurin through the Phosphorylation of Modulatory Calcineurin-interacting Protein 1*
Calcineurin is a serine/threonine protein phosphatase that plays a critical role in many physiologic processes such as T-cell… 
2005
2005
A Novel Mitogen-Activated Protein Kinase Docking Site in the N Terminus of MEK5α Organizes the Components of the Extracellular Signal-Regulated Kinase 5 Signaling Pathway
ABSTRACT The alternative splicing of the mek5 gene gives rise to two isoforms. MEK5β lacks an extended N terminus present in MEK5… 
2005
2005
c-myc Promoter-binding Protein 1 (MBP-1) Regulates Prostate Cancer Cell Growth by Inhibiting MAPK Pathway*
Prostate cancer is the most common and invasive type of cancer among American men, and the second leading cause of cancer-elated… 
2004
2004
Characterization of the MEK5-ERK5 Module in Human Neutrophils and Its Relationship to ERK1/ERK2 in the Chemotactic Response*
The role of the extracellular signal-regulated kinase (ERK) 1 and ERK2 in the neutrophil chemotactic response remains to be… 
2004
2004
Differential role of MEK5alpha and MEK5beta in BMK1/ERK5 activation.
Big mitogen-activated protein kinase 1/extracellular-regulated kinase 5 (BMK1/ERK5) is regulated sequentially by a series of… 
Highly Cited
2001
Highly Cited
2001
Activation of BMK1 via tyrosine 1062 in RET by GDNF and MEN2A mutation.
Big mitogen-activated protein kinase 1 (BMK1) is a new member of mitogen-activated protein kinase (MAPK) family. In the present… 
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