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Lys05

National Institutes of Health

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Lys01

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Chloroquine Derivative Lys05 Overcomes Hypoxia-Induced Chemoresistance in Acute Myeloid Leukemia through Metabolic Disruption
Background: Despite initial responses to standard chemotherapy, most patients with acute myeloid leukemia (AML) relapse and… 
2017
2017
Abstract 3317: Autophagy protects ovarian cancer cells from olaparib-induced toxicity
Ovarian cancer (OC) is the most lethal gynecologic malignancy. Persistence of dormant, drug resistant cancer cells is one of the… 
2016
2016
Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma.
Clear cell ovarian carcinoma (CCOC) is an aggressive form of epithelial ovarian cancer that exhibits low response rates to… 
2016
2016
Abstract 1018: Structural features of novel dimeric quinacrines that have single-agent antitumor activity determine the mechanism of action: destabilization of mTORC1/lysosomal interaction versus DNA…
The safety and preliminary activity of hydroxychloroquine in phase I cancer clinical trials have established the feasibility and… 
2015
2015
Abstract 2902: The effectiveness of autophagy inhibition in sensitizing triple-negative breast cancer cells to chemotherapy
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Introduction: High recurrence rates, drug… 
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