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Licofelone

Known as: 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid, (2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetic acid, 2,3-Dihydro-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid 
 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

ML-3000

Broader (1)

Pyrroles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Licofelone Modulates Neuroinflammation and Attenuates Mechanical Hypersensitivity in the Chronic Phase of Spinal Cord Injury
Inflammation is a major factor shaping outcome during the early, acute phase of traumatic spinal cord injury (SCI). It is known… Expand
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Highly Cited
2009
Highly Cited
2009
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI
Objective: In a multicentre study to explore the effects of licofelone as a disease-modifying osteoarthritis drug in comparison… Expand
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Highly Cited
2008
Highly Cited
2008
Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1
The anti-inflammatory drug licofelone [=ML3000; 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl… Expand
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Highly Cited
2008
Highly Cited
2008
Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade.
Nowadays, no data are available concerning the potential use of dual cyclooxygenase (COX)/5-lipoxygenase (LOX) inhibitors as… Expand
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Highly Cited
2007
Highly Cited
2007
Licofelone, a Balanced Inhibitor of Cyclooxygenase and 5-Lipoxygenase, Reduces Inflammation in a Rabbit Model of Atherosclerosis
Licofelone, a dual anti-inflammatory drug that inhibits 5-lipoxygenase (LOX) and cyclooxygenase (COX) enzymes, may have a better… Expand
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2007
2007
Efficacy of licofelone in dogs with clinical osteoarthritis
To evaluate the effect of licofelone, an arachidonic acid substrate with combined inhibitory activity against 5-lipoxygenase and… Expand
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2005
2005
Superiority of the gastroduodenal safety profile of licofelone over rofecoxib, a COX-2 selective inhibitor, in dogs.
This study assessed the gastroduodenal safety profile of licofelone, a new nonsteroidal anti-inflammatory drug with dual… Expand
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Highly Cited
2004
Highly Cited
2004
The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K.
OBJECTIVE To evaluate the morphological changes that take place in the subchondral bone and calcified cartilage zone in the… Expand
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Highly Cited
2004
Highly Cited
2004
The Gastrointestinal Tolerability of the LOX/COX Inhibitor, Licofelone, is Similar to Placebo and Superior to Naproxen Therapy in Healthy Volunteers: Results From a Randomized, Controlled Trial
OBJECTIVES:Concerns exist over the safety of conventional nonsteroidal antiinflammatory drugs (NSAIDs) and selective… Expand
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Review
2004
Review
2004
Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis.
Licofelone, a competitive inhibitor of 5-lipoxygenase, cyclooxygenase (COX)-1 and COX-2, is currently in clinical development for… Expand
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