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Licofelone

Known as: 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid, (2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetic acid, 2,3-Dihydro-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

ML-3000

Broader (1)

Pyrroles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2014
Review
2014
The role of inflammation in colon cancer.
Colorectal cancer (CRC) is the one of the leading causes of cancer-related deaths in the world. CRC is responsible for more than… 
Review
2014
Review
2014
Neuroinflammatory contributions to pain after SCI: Roles for central glial mechanisms and nociceptor-mediated host defense
  • E. Walters
  • Experimental Neurology
  • 2014
  • Corpus ID: 39671969
Review
2011
Review
2011
Role of lipoxins, resolvins, and other bioactive lipids in colon and pancreatic cancer
Unresolved inflammation, due to insufficient production of proresolving anti-inflammatory lipid mediators, can lead to an… 
Highly Cited
2009
Highly Cited
2009
Protective effects of licofelone, a 5-lipoxygenase and cyclo-oxygenase inhibitor, versus naproxen on cartilage loss in knee osteoarthritis: a first multicentre clinical trial using quantitative MRI
Objective: In a multicentre study to explore the effects of licofelone as a disease-modifying osteoarthritis drug in comparison… 
Highly Cited
2008
Highly Cited
2008
Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1
The anti-inflammatory drug licofelone [=ML3000; 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl… 
Highly Cited
2008
Highly Cited
2008
Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade.
Nowadays, no data are available concerning the potential use of dual cyclooxygenase (COX)/5-lipoxygenase (LOX) inhibitors as… 
Highly Cited
2007
Highly Cited
2007
Licofelone, a Balanced Inhibitor of Cyclooxygenase and 5-Lipoxygenase, Reduces Inflammation in a Rabbit Model of Atherosclerosis
Licofelone, a dual anti-inflammatory drug that inhibits 5-lipoxygenase (LOX) and cyclooxygenase (COX) enzymes, may have a better… 
Highly Cited
2004
Highly Cited
2004
The Gastrointestinal Tolerability of the LOX/COX Inhibitor, Licofelone, is Similar to Placebo and Superior to Naproxen Therapy in Healthy Volunteers: Results From a Randomized, Controlled Trial
OBJECTIVES:Concerns exist over the safety of conventional nonsteroidal antiinflammatory drugs (NSAIDs) and selective… 
Review
2004
Review
2004
Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis.
Licofelone, a competitive inhibitor of 5-lipoxygenase, cyclooxygenase (COX)-1 and COX-2, is currently in clinical development for… 
Review
2003
Review
2003
Dual inhibition of cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) as a new strategy to provide safer non-steroidal anti-inflammatory drugs.
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