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Licofelone

Known as: 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid, (2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetic acid, 2,3-Dihydro-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid 
 
National Institutes of Health

Papers overview

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2013
2013
Inflammation is a major factor shaping outcome during the early, acute phase of traumatic spinal cord injury (SCI). It is known… Expand
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Highly Cited
2009
Highly Cited
2009
Objective: In a multicentre study to explore the effects of licofelone as a disease-modifying osteoarthritis drug in comparison… Expand
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Highly Cited
2008
Highly Cited
2008
The anti-inflammatory drug licofelone [=ML3000; 2-[6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl… Expand
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Highly Cited
2008
Highly Cited
2008
Nowadays, no data are available concerning the potential use of dual cyclooxygenase (COX)/5-lipoxygenase (LOX) inhibitors as… Expand
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Highly Cited
2007
Highly Cited
2007
Licofelone, a dual anti-inflammatory drug that inhibits 5-lipoxygenase (LOX) and cyclooxygenase (COX) enzymes, may have a better… Expand
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2007
2007
To evaluate the effect of licofelone, an arachidonic acid substrate with combined inhibitory activity against 5-lipoxygenase and… Expand
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2005
2005
This study assessed the gastroduodenal safety profile of licofelone, a new nonsteroidal anti-inflammatory drug with dual… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE To evaluate the morphological changes that take place in the subchondral bone and calcified cartilage zone in the… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVES:Concerns exist over the safety of conventional nonsteroidal antiinflammatory drugs (NSAIDs) and selective… Expand
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Review
2004
Review
2004
Licofelone, a competitive inhibitor of 5-lipoxygenase, cyclooxygenase (COX)-1 and COX-2, is currently in clinical development for… Expand
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