Skip to search formSkip to main contentSkip to account menu

Licofelone

Known as: 6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid, (2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetic acid, 2,3-Dihydro-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

ML-3000

Broader (1)

Pyrroles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Synthesis of diarylidenecyclohexanone derivatives as potential anti-inflammatory leads against COX-2/mPGES1 and 5-LOX
This study establishes the diarylidenecyclohexanones as good anti-inflammatory pharmacophores with selective high potency against… 
2014
2014
Chemoprevention of Urothelial Cell Carcinoma Growth and Invasion by the Dual COX–LOX Inhibitor Licofelone in UPII-SV40T Transgenic Mice
Epidemiologic and clinical data suggest that use of anti-inflammatory agents is associated with reduced risk for bladder cancer… 
2012
2012
Polypharmacology in drug discovery
List of contributors. Preface. Introduction: the case for polypharmacology Andrew L. Hopkins Part A: Polypharmacology a safety… 
Highly Cited
2012
Highly Cited
2012
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.
Human 5-lipoxygenase (5-LOX) is one of the key anti-inflammatory drug targets due to its key role in leukotrienes biosynthesis… 
2011
2011
Chemopreventive Efficacy and Mechanism of Licofelone in a Mouse Lung Tumor Model via Aspiration
Our previous study comparing inhalation and aspiration to administer agents directly to lung indicated that aspiration route is… 
2005
2005
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation.
The present study was aimed to evaluate the effect of licofelone, a dual inhibitor of cycloxygenase1/2-5-lipoxygenase against… 
Review
2004
Review
2004
Osteoarthritis therapy--are there still unmet needs?
Non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase (COX)-2 inhibitors are commonly used to control pain… 
2004
2004
Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation.
Highly Cited
2003
Highly Cited
2003
Evidence that 5‐lipoxygenase and acetylated cyclooxygenase 2‐derived eicosanoids regulate leukocyte–endothelial adherence in response to aspirin
Unlike other nonsteroidal anti‐inflammatory drugs that inhibit formation of cyclooxygenase (COX)‐dependent eicosanoids… 
2002
2002
First clinical results of licofelone (ml3000), an inhibitor of COX-1, COX-2 and 5-LOX, for the treatment of osteoarthritis
full series of preclinical studies. The GI, renal, hepatic and general tolerability was excellent. In clinical phase II and phase… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)