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Licofelone
Known as:
6-(4-Chlorophenyl)-2,3-dihydro-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid
, (2,2-dimethyl-6-(4-chlorophenyl)-7-phenyl-2,3-dihydro-1H-pyrrolizine-5-yl)acetic acid
, 2,3-Dihydro-6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-1H-pyrrolizine-5-acetic Acid
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National Institutes of Health
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Related topics
Related topics
2 relations
Narrower (1)
ML-3000
Broader (1)
Pyrroles
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Synthesis of diarylidenecyclohexanone derivatives as potential anti-inflammatory leads against COX-2/mPGES1 and 5-LOX
Swayamsiddha Kar
,
Gayathri Ramamoorthy
,
+7 authors
M. Doble
New Journal of Chemistry
2019
Corpus ID: 181960323
This study establishes the diarylidenecyclohexanones as good anti-inflammatory pharmacophores with selective high potency against…
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2014
2014
Chemoprevention of Urothelial Cell Carcinoma Growth and Invasion by the Dual COX–LOX Inhibitor Licofelone in UPII-SV40T Transgenic Mice
Venkateshwar Madka
,
Altaf Mohammed
,
+8 authors
C. Rao
Cancer Prevention Research
2014
Corpus ID: 3395315
Epidemiologic and clinical data suggest that use of anti-inflammatory agents is associated with reduced risk for bladder cancer…
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2012
2012
Polypharmacology in drug discovery
J. Peters
2012
Corpus ID: 70678495
List of contributors. Preface. Introduction: the case for polypharmacology Andrew L. Hopkins Part A: Polypharmacology a safety…
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Highly Cited
2012
Highly Cited
2012
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.
Yiran Wu
,
C. He
,
Yang Gao
,
Shan He
,
Y. Liu
,
L. Lai
Journal of Medicinal Chemistry
2012
Corpus ID: 28681608
Human 5-lipoxygenase (5-LOX) is one of the key anti-inflammatory drug targets due to its key role in leukotrienes biosynthesis…
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2011
2011
Chemopreventive Efficacy and Mechanism of Licofelone in a Mouse Lung Tumor Model via Aspiration
Sheela Sharma
,
Jin Lee
,
Jianliang Zhou
,
V. Steele
Cancer Prevention Research
2011
Corpus ID: 10544272
Our previous study comparing inhalation and aspiration to administer agents directly to lung indicated that aspiration route is…
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2005
2005
Effect of licofelone against NSAIDs-induced gastrointestinal ulceration and inflammation.
Vijay P. Singh
,
C. S. Patil
,
S. Kulkarni
Indian journal of experimental biology
2005
Corpus ID: 157486
The present study was aimed to evaluate the effect of licofelone, a dual inhibitor of cycloxygenase1/2-5-lipoxygenase against…
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Review
2004
Review
2004
Osteoarthritis therapy--are there still unmet needs?
S. Laufer
Rheumatology
2004
Corpus ID: 22685009
Non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase (COX)-2 inhibitors are commonly used to control pain…
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2004
2004
Licofelone, an inhibitor of cyclooxygenase and 5-lipoxygenase, specifically inhibits cyclooxygenase-1-dependent platelet activation.
S. Rotondo
,
K. Krauze-Brzósko
,
S. Manarini
,
V. Evangelista
,
C. Cerletti
European Journal of Pharmacology
2004
Corpus ID: 25348567
Highly Cited
2003
Highly Cited
2003
Evidence that 5‐lipoxygenase and acetylated cyclooxygenase 2‐derived eicosanoids regulate leukocyte–endothelial adherence in response to aspirin
S. Fiorucci
,
E. Distrutti
,
+4 authors
J. Wallace
British Journal of Pharmacology
2003
Corpus ID: 25086588
Unlike other nonsteroidal anti‐inflammatory drugs that inhibit formation of cyclooxygenase (COX)‐dependent eicosanoids…
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2002
2002
First clinical results of licofelone (ml3000), an inhibitor of COX-1, COX-2 and 5-LOX, for the treatment of osteoarthritis
J. Reginster
,
P. Bias
,
A. Buchner
2002
Corpus ID: 68002360
full series of preclinical studies. The GI, renal, hepatic and general tolerability was excellent. In clinical phase II and phase…
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