Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative

Known as: Leukemia, Myeloid, Chronic, Atypical, Leukemia, Philadelphia-Negative Myeloid, ACML 
A myelodysplastic/myeloproliferative disorder characterized by myelodysplasia associated with bone marrow and peripheral blood patterns similar to… (More)
National Institutes of Health

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AnemiaBone MarrowBone marrow stem cellCCDC6 gene
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Papers overview

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Review
2017
Review
2017
Role of RUNX1 in hematological malignancies.
RUNX1 is a member of the core-binding factor family of transcription factors and is indispensable for the establishment of… (More)
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Highly Cited
2013
Highly Cited
2013
Recurrent SETBP1 mutations in atypical chronic myeloid leukemia
Atypical chronic myeloid leukemia (aCML) shares clinical and laboratory features with CML, but it lacks the BCR-ABL1 fusion. We… (More)
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Highly Cited
2013
Highly Cited
2013
Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML.
BACKGROUND The molecular causes of many hematologic cancers remain unclear. Among these cancers are chronic neutrophilic leukemia… (More)
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Highly Cited
2010
Highly Cited
2010
Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The… (More)
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Highly Cited
2010
Highly Cited
2010
Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13.
Myeloid-derived suppressor cells (MDSCs) are a well-defined population of cells that accumulate in the tissue of tumor-bearing… (More)
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Highly Cited
2009
Highly Cited
2009
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms
Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated… (More)
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Highly Cited
2008
Highly Cited
2008
Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis.
Aberrant TGFbeta signaling is common in human cancers and contributes to tumor metastasis. Here, we demonstrate that Gr-1+CD11b… (More)
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Review
2005
Review
2005
Pathogenesis of myelofibrosis with myeloid metaplasia.
  • Ayalew Tefferi
  • Journal of clinical oncology : official journal…
  • 2005
The primary disease process in myelofibrosis with myeloid metaplasia (MMM) is clonal myeloproliferation with varying degrees of… (More)
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Highly Cited
2003
Highly Cited
2003
Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9.
Transcriptional deregulation through the production of dominant-acting chimeric transcription factors derived from chromosomal… (More)
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Highly Cited
2002
Highly Cited
2002
Critical role for Gab2 in transformation by BCR/ABL.
The BCR/ABL oncogene causes chronic myelogenous leukemia (CML) in humans and a CML-like disease, as well as lymphoid leukemia, in… (More)
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