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Lecithin Acyltransferase Deficiency

Known as: Norum Disease, Deficiency, LCAT, LECITHIN:CHOLESTEROL ACYLTRANSFERASE DEFICIENCY 
An autosomal recessive disorder of lipoprotein metabolism caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE gene. It is characterized by low… Expand
National Institutes of Health

Related topics

Related topics

13 relations
Anemia, HemolyticAutosomal recessive inheritanceIn BloodKidney Failure
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Broader (1)

Enzyme Deficiency

Narrower (1)

Fish-Eye Disease

Papers overview

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Highly Cited
2009
Highly Cited
2009
Modification of High Density Lipoprotein by Myeloperoxidase Generates a Pro-inflammatory Particle*
High density lipoprotein (HDL) is the major atheroprotective particle in plasma. Recent studies demonstrate that myeloperoxidase… Expand
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Highly Cited
2004
Highly Cited
2004
Lecithin-retinol Acyltransferase Is Essential for Accumulation of All-trans-Retinyl Esters in the Eye and in the Liver*
Lecithin-retinol acyltransferase (LRAT), an enzyme present mainly in the retinal pigmented epithelial cells and liver, converts… Expand
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Highly Cited
2004
Highly Cited
2004
Atherogenic index of plasma [log(triglycerides/HDL-cholesterol)]: theoretical and practical implications.
In individuals with type 2 diabetes, metabolic syndrome, and the combined dyslipidemia, cardiovascular risk is increased by a… Expand
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Highly Cited
2001
Highly Cited
2001
Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism
Maturity-onset diabetes of the young type 3 (MODY3) is caused by haploinsufficiency of hepatocyte nuclear factor-1α (encoded by… Expand
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Highly Cited
1999
Highly Cited
1999
Molecular and Biochemical Characterization of Lecithin Retinol Acyltransferase*
The enzyme responsible for conversion of all-trans-retinol into retinyl esters, the lecithin retinol acyltransferase (LRAT) has… Expand
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Highly Cited
1976
Highly Cited
1976
Determination of apolipoprotein A and its constitutive A-I and A-II polypeptides by separate electroimmunoassays.
Electroimmunoassays ("rocket" electrophoresis) are described for human serum apolipoprotein A and its constitutive A-I and A-II… Expand
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Review
1973
Review
1973
The metabolic role of lecithin: cholesterol acyltransferase: perspectives from pathology.
  • J. Glomset
  • Advances in lipid research
  • 1973
    • Corpus ID: 27645149
Publisher Summary This chapter discusses the metabolic role of enzyme lecithin called cholesterol acyltransferase (LCAT). The… Expand
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Highly Cited
1971
Highly Cited
1971
Lipid spin labels in lecithin multilayers. A study of motion along fatty acid chains.
Oriented multilayers may be prepared by drying phospholipid dispersions on a glass slide. They provide a convenient model with… Expand
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Highly Cited
1971
Highly Cited
1971
Laser Raman investigation of the effect of cholesterol on conformational changes in dipalmitoyl lecithin multilayers.
Large and abrupt changes are observed at 38 degrees C in the 1100 cm(-1) region of the Raman spectrum of aqueous dipalmitoyl… Expand
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Highly Cited
1970
Highly Cited
1970
Plasma lipoproteins in familial lecithin: cholesterol acyltransferase deficiency: lipid composition and reactivity in vitro.
Plasma lipoproteins from patients with familial lecithin:cholesterol acyltransferase (LCAT) deficiency have been fractioned by… Expand
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