Last Observation Carried Forward Imputation Technique

Known as: LOCF 
The substitution of missing data with the most recent data collected that is not missing.
National Institutes of Health

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CDISC ADaM Derivation Type TerminologyClinical Data Interchange Standards Consortium Terminology

Papers overview

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Highly Cited
2011
Highly Cited
2011
Primary care referral to a commercial provider for weight loss treatment versus standard care: a randomised controlled trial
BACKGROUND The increasing prevalence of overweight and obesity needs effective approaches for weight loss in primary care and… (More)
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2009
2009
Last observation carried forward: a crystal ball?
In spite of widespread criticism and notwithstanding the availability of flexible, broadly valid, and conveniently implemented… (More)
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Highly Cited
2009
Highly Cited
2009
A Study of Dapagliflozin in Patients With Type 2 Diabetes Receiving High Doses of Insulin Plus Insulin Sensitizers
OBJECTIVE To determine whether dapagliflozin, which selectively inhibits renal glucose reabsorption, lowers hyperglycemia in… (More)
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Highly Cited
2008
Highly Cited
2008
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer's disease: a randomised, double-blind, placebo-controlled study
BACKGROUND Although treatments for Alzheimer's disease sometimes improve cognition, functional ability, or behaviour compared… (More)
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Highly Cited
2006
Highly Cited
2006
Comparison of etanercept and methotrexate, alone and combined, in the treatment of rheumatoid arthritis: two-year clinical and radiographic results from the TEMPO study, a double-blind, randomized…
OBJECTIVE To evaluate the efficacy, including radiographic changes, and safety of etanercept and methotrexate (MTX), used in… (More)
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Highly Cited
2005
Highly Cited
2005
Vagus Nerve Stimulation for Treatment-Resistant Depression: A Randomized, Controlled Acute Phase Trial
BACKGROUND Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional… (More)
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Highly Cited
2004
Highly Cited
2004
The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease.
OBJECTIVE To determine the efficacy of donepezil in the treatment of neuropsychiatric symptoms in patients with Alzheimer disease… (More)
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Highly Cited
2002
Highly Cited
2002
The Emperor's New Drugs: An Analysis of Antidepressant Medication Data Submitted to the U.S. Food and Drug Administration
This article reports an analysis of the efficacy data submitted to the U.S. Food and Drug Administration for approval of the 6… (More)
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Highly Cited
2001
Highly Cited
2001
A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease.
OBJECTIVE To investigate the efficacy and safety of donepezil in patients with moderate to severe AD (standardized Mini-Mental… (More)
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Highly Cited
1998
Highly Cited
1998
A comparison of the random-effects pattern mixture model with last-observation-carried-forward (LOCF) analysis in longitudinal clinical trials with dropouts.
The last-observation-carried-forward imputation method is commonly used for imputting data missing due to dropouts in… (More)
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