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Lapaquistat Acetate

Known as: 2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3- dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo(e)(1,4)oxazepin-3- yl)acetyl)piperidin-4-yl)acetic Acid 
An acetate salt form of lapaquistat, a squalene synthase inhibitor investigated for the treatment of hypercholesterolemia.
National Institutes of Health

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TAK-475

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2016
2016
Characterization of Transporters in the Hepatic Uptake of TAK-475 M-I, a Squalene Synthase Inhibitor, in Rats and Humans
Abstract TAK-475 (lapaquistat acetate) is a squalene synthase inhibitor and M-I is a pharmacologically active metabolite of TAK… 
2007
2007
Abstract 193: Lapaquistat Acetate, A Novel Squalene Synthase Inhibitor, Co-administered with Atorvastatin Reduces Plasma Lipids and C-Reactive Protein Levels in Subjects with Primary…
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