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LYST gene

Known as: Lysosomal Trafficking Regulator Gene, LYSOSOMAL TRAFFICKING REGULATOR, CHS1 GENE 
This gene plays a role in lysosomal protein trafficking and mutations in the gene cause Chediak-Higashi syndrome.
National Institutes of Health

Related topics

Related topics

8 relations
CHS proteinChediak-Higashi SyndromeHomo sapiensIntracellular Transport

Papers overview

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Highly Cited
2010
Highly Cited
2010
Differential expression of CHS7 and CHS8 genes in soybean
Chalcone synthase (CHS) catalyzes the first reaction specific for flavonoid and isoflavonoid biosynthesis. The soybean genome… 
Highly Cited
2009
Highly Cited
2009
Sensitization of Cutaneous Nociceptors after Nerve Transection and Regeneration: Possible Role of Target-Derived Neurotrophic Factor Signaling
Damage to peripheral nerves is known to contribute to chronic pain states, including mechanical and thermal hyperalgesia and… 
Highly Cited
2008
Highly Cited
2008
Control of Parasitophorous Vacuole Expansion by LYST/Beige Restricts the Intracellular Growth of Leishmania amazonensis
The intracellular protozoan Leishmania replicates in parasitophorous vacuoles (PV) that share many features with late endosomes… 
Highly Cited
2006
Highly Cited
2006
RNAi-induced silencing of gene expression in strawberry fruit (Fragaria x ananassa) by agroinfiltration: a rapid assay for gene function analysis.
Intron-containing constructs encoding self-complementary 'hairpin' RNA (ihpRNA) have the potential to efficiently silence genes… 
Highly Cited
2004
Highly Cited
2004
Features of a 103-kb gene-rich region in soybean include an inverted perfect repeat cluster of CHS genes comprising the I locus.
The I locus in soybean (Glycine max) corresponds to a region of chalcone synthase (CHS) gene duplications affecting seed… 
Highly Cited
2003
Highly Cited
2003
Stilbenecarboxylate biosynthesis: a new function in the family of chalcone synthase-related proteins.
Highly Cited
1997
Highly Cited
1997
Mutations in the Chediak-Higashi syndrome gene (CHS1) indicate requirement for the complete 3801 amino acid CHS protein.
Chediak-Higashi syndrome (CHS) is a rare, usually fatal, autosomal recessive disorder characterized by severe immunologic defects… 
Highly Cited
1996
Highly Cited
1996
Duplications That Suppress and Deletions That Restore Expression from a Chalcone Synthase Multigene Family.
Seed coat color in soybean is determined by four alleles of the classically defined / (inhibitor) locus that controls the… 
Highly Cited
1995
Highly Cited
1995
Reaction mechanisms of homodimeric plant polyketide synthase (stilbenes and chalcone synthase). A single active site for the condensing reaction is sufficient for synthesis of stilbenes, chalcones…
Stilbene (STS) and chalcone (CHS) synthases are homodimeric, related plant-specific polyketide synthases. Both perform a… 
Highly Cited
1986
Highly Cited
1986
Chitin synthetase 2, a presumptive participant in septum formation in Saccharomyces cerevisiae.
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