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LY2409021

 
National Institutes of Health

Papers overview

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2019
2019
G protein–coupled receptors (GPCRs) for glucagon (GluR) and glucagon-like peptide-1 (GLP-1R) are normally considered to be highly… Expand
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2018
2018
LY2409021 is a glucagon receptor antagonist that was associated with hepatic steatosis and elevated aminotransferases in phase 2… Expand
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2017
2017
AIMS To evaluate whether treatment with LY2409021, a novel, selective glucagon receptor antagonist, is associated with changes in… Expand
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2017
2017
AIMS To assess the effect of LY2409021 on systolic blood pressure (SBP) in patients with type 2 diabetes. MATERIALS AND METHODS… Expand
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2016
2016
Since the discovery of glucagon’s opposing actions to insulin, drugs targeting the inhibition of glucagon action have been… Expand
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2016
2016
We would like to congratulate Kazda et al. (1) for reporting the first phase 2 study of the glucagon receptor antagonist… Expand
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Highly Cited
2015
Highly Cited
2015
OBJECTIVE Type 2 diabetes pathophysiology is characterized by dysregulated glucagon secretion. LY2409021, a potent, selective… Expand
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Highly Cited
2015
Highly Cited
2015
AIM To describe the clinical effects of single and multiple doses of a potent, selective, orally administered, small-molecule… Expand
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Highly Cited
2015
Highly Cited
2015
The first copper-catalyzed ring-opening electrophilic trifluoromethylation and trifluoromethylthiolation of cyclopropanols to… Expand
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2014
2014
BackgroundInteraction of the small peptide hormone glucagon with glucagon receptor (GCGR) stimulates the release of glucose from… Expand
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