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LY 3039478

Known as: LY-3039478, LY3039478 
National Institutes of Health

Papers overview

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2020
2020
Crenigacestat, a selective NOTCH1 inhibitor, reduces intrahepatic cholangiocarcinoma progression by blocking VEGFA/DLL4/MMP13 axis
Intrahepatic cholangiocarcinoma (iCCA) is a deadly disease with rising incidence and few treatment options. An altered expression… 
2019
2019
Abstract A58: Notch signaling is a key regulator for immune-suppressive function of tumor-associated macrophages in pancreatic adenocarcinoma
Objective: Pancreatic ductal adenocarcinoma (PDA) has the most dismal prognosis among all human cancers. The poor survival rate… 
2018
2018
Abstract 2043: PlGF/VEGFR-1-dependent activation of Dll4/Notch4 pathway contributes to liver vessel abnormalities and tumor growth in hepatocellular carcinoma
Background: Hepatocellular carcinoma (HCC) is characterized by strong abnormalities of liver vasculature linked to proangiogenic… 
2017
2017
Notch pathway inhibition with LY3039478 in adenoid cystic carcinoma (ACC).
6024Background: ACCs have high levels of Notch-1 receptor expression and activation. LY3039478 (LY) is an orally bioavailable… 
2017
2017
Abstract 4044: LY3039579, a novel Notch inhibit, potentiates the anti-tumoral effects of sorafenib in hepatocellular carcinoma (HCC)
Introduction: Notch pathway has been involved in cell fate determination, cell differentiation, proliferation and death. Notch… 
Review
2017
Review
2017
New NCI drug formulary cuts red tape
(nivolumab), both of which are already being studied in a number of combination trials in humans. Hambleton hopes participating… 
2017
2017
1482PDNotch pathway inhibition with LY3039478 in soft tissue sarcoma (STS) and gastrointestinal stromal tumours (GIST)
2015
2015
First-in-human study of LY3039478, a Notch signaling inhibitor in advanced or metastatic cancer.
2533 Background: LY3039478 (LY) is an orally bioavailable, potent, and highly selective Notch inhibitor (Notch 1-4). We report on… 
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