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LY 303511

Known as: LY-303511, LY303511 
National Institutes of Health

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2 relations

Broader (2)

ChromonesPiperazines

Papers overview

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Highly Cited
2014
Highly Cited
2014
The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains.
A commonly used small-molecule probe in cell-signaling research is the phosphoinositide 3-kinase inhibitor LY294002. Quantitative… 
Highly Cited
2009
Highly Cited
2009
Polar bacterial invasion and translocation of Streptococcus suis across the blood‐cerebrospinal fluid barrier in vitro
Previous experimental studies in a standard Transwell culture system have shown Streptococcus suis ability to compromise barrier… 
Highly Cited
2007
Highly Cited
2007
Role of reactive oxygen species in protein degradation in murine myotubes induced by proteolysis-inducing factor and angiotensin II.
Highly Cited
2006
Highly Cited
2006
Insulin induces heme oxygenase‐1 through the phosphatidylinositol 3‐kinase/Akt pathway and the Nrf2 transcription factor in renal cells
Heme oxygenase‐1 catalyzes the breakdown of heme and is protective in models of kidney transplantation. In this study we describe… 
Highly Cited
2005
Highly Cited
2005
LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway.
The phosphoinositide 3-kinase (PI3K)-Akt pathway is constitutively active in many tumors, and inhibitors of this prosurvival… 
Highly Cited
2005
Highly Cited
2005
Insulin Stimulates Postsynaptic Density-95 Protein Translation via the Phosphoinositide 3-Kinase-Akt-Mammalian Target of Rapamycin Signaling Pathway*
Insulin receptors are highly enriched at neuronal synapses, but whose function remains unclear. Here we present evidence that… 
Highly Cited
2005
Highly Cited
2005
Regulation of cholinergic gene expression by nerve growth factor depends on the phosphatidylinositol‐3′‐kinase pathway
Nerve growth factor (NGF) exerts anti‐apoptotic, trophic and differentiating actions on sympathetic neurons and cholinergic cells… 
Highly Cited
2003
Highly Cited
2003
The phosphatidylinositol 3‐kinase inhibitor LY294002 potently blocks Kv currents via a direct mechanism
  • W. El-kholy, P. MacDonald, Michael B. Wheeler
  • FASEB journal : official publication of the…
  • 2003
  • Corpus ID: 24976669
Voltage‐dependent K+ (Kv) channels negatively regulate Ca2+ entry into pancreatic β‐cells by repolarizing glucose‐stimulated… 
Highly Cited
2000
Highly Cited
2000
Phosphatidylinositol 3-Kinase Activation and Interaction with Focal Adhesion Kinase in Escherichia coli K1 Invasion of Human Brain Microvascular Endothelial Cells*
Invasion of brain microvascular endothelial cells (BMEC) is a prerequisite for successful crossing of the blood-brain barrier by… 
Highly Cited
1995
Highly Cited
1995
Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils
Several novel protein kinases are known to be rapidly activated in neutrophils stimulated with the chemoattractant fMet-Leu-Phe… 
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