Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

LY 290181

Known as: LY-290181, LY290181 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

NaphthalenesPyrans

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents.
A series of 19 analogues of the antiproliferative naphthopyran LY290181 were prepared for structure-activity relationship studies… Expand
Is this relevant?
1998
1998
Polyphenol-mediated inhibition of AP-1 transactivating activity may slow cancer growth by impeding angiogenesis and tumor invasiveness.
Certain polyphenols, capable of activating transcription via antioxidant response elements, potently induce Fra-1/Fra-2, thereby… Expand
Is this relevant?
1997
1997
Suppression of Microtubule Dynamics by LY290181
LY290181, 2-amino-4-(3-pyridyl)-4H-naphtho(1,2-b)pyran-3-carbonitrile, is a potent antiproliferative compound that blocks cells… Expand
  • figure 1
  • table I
  • figure 2
  • figure 3
  • table II
Is this relevant?
1997
1997
Inhibition of mitosis and microtubule function through direct tubulin binding by a novel antiproliferative naphthopyran LY290181.
The mechanism of action of a novel antiproliferative compound LY290181 [2-amino-4-(3-pyridyl)-4H-naphtho(1,2-b)pyran-3… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 5
Is this relevant?
1996
1996
LY290181, an inhibitor of diabetes-induced vascular dysfunction, blocks protein kinase C-stimulated transcriptional activation through inhibition of transcription factor binding to a phorbol response…
Previous studies have shown that high glucose levels and diabetes induce an elevation in protein kinase C (PKC) activity in… Expand
Is this relevant?
1996
1996
Inhibition of vascular smooth muscle cell proliferation and arterial intimal thickening by a novel antiproliferative naphthopyran.
Smooth muscle cell proliferation plays an important role in neointimal thickening after vascular injury and may contribute to… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE