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LY 290181

Known as: LY-290181, LY290181 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

NaphthalenesPyrans

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
New naphthopyran analogues of LY290181 as potential tumor vascular-disrupting agents.
A series of 19 analogues of the antiproliferative naphthopyran LY290181 were prepared for structure-activity relationship studies… Expand
1998
1998
Polyphenol-mediated inhibition of AP-1 transactivating activity may slow cancer growth by impeding angiogenesis and tumor invasiveness.
  • M. Mccarty
  • Medical hypotheses
  • 1998
    • Corpus ID: 42845774
Certain polyphenols, capable of activating transcription via antioxidant response elements, potently induce Fra-1/Fra-2, thereby… Expand
1997
1997
Suppression of Microtubule Dynamics by LY290181
LY290181, 2-amino-4-(3-pyridyl)-4H-naphtho(1,2-b)pyran-3-carbonitrile, is a potent antiproliferative compound that blocks cells… Expand
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1997
1997
Inhibition of mitosis and microtubule function through direct tubulin binding by a novel antiproliferative naphthopyran LY290181.
The mechanism of action of a novel antiproliferative compound LY290181 [2-amino-4-(3-pyridyl)-4H-naphtho(1,2-b)pyran-3… Expand
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1996
1996
LY290181, an Inhibitor of Diabetes-Induced Vascular Dysfunction, Blocks Protein Kinase C—Stimulated Transcriptional Activation Through Inhibition of Transcription Factor Binding to a Phorbol Response…
Previous studies have shown that high glucose levels and diabetes induce an elevation in protein kinase C (PKC) activity in… Expand
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1996
1996
Inhibition of vascular smooth muscle cell proliferation and arterial intimal thickening by a novel antiproliferative naphthopyran.
Smooth muscle cell proliferation plays an important role in neointimal thickening after vascular injury and may contribute to… Expand
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