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LY 2181308

Known as: LY-2181308, Antisurvivin Antisense Oligonucleotide LY2181308, LY2181308 Heptadecasodium Salt 
National Institutes of Health

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1 relation

Broader (1)

Oligonucleotides

Papers overview

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2013
2013
A randomized open-label phase II study evaluating antitumor activity of the survivin antisense oligonucleotide LY2181308 (LY) in combination with docetaxel (DO) for second-line treatment of patients…
8051^ Background: Resistance to chemotherapy in progressive NSCLC is associated with overexpression of antiapoptotic proteins… 
2011
2011
Randomized phase II study with window-design to evaluate anti-tumor activity of the survivin antisense oligonucleotide (ASO) ly2181308 in combination with docetaxel for first-line treatment of…
5019 Background: In prostate cancer, expression of survivin, a protein that inhibits apoptosis, is associated with resistance to… 
2011
2011
Interim results of a randomized phase II study with window-design to evaluate antitumor activity of the survivin antisense oligonucleotide (ASO) LY2181308 in combination with docetaxel for first-line…
4592 Background: Survivin is a member of the inhibitor of apoptosis proteins (IAP). Its expression in prostate cancer is… 
2009
2009
Microdosing imaging pharmacokinetic (PK) study of the antisense oligonucleotide (ASO) to survivin (LY2181308) using positron emission tomography (PET): A novel paradigm in clinical drug development.
3578 Background: Survivin, an inhibitor of an apoptosis protein, widely overexpressed in cancer is associated with poor clinical… 
2009
2009
Pharmacodynamic (PD) evaluation of LY2181308 in patients with metastatic malignancies.
3507 Background: Survivin is an inhibitor of apoptosis and its overexpression in cancer has been associated with poor survival… 
2009
2009
Abstract B48: A phase 1 study of an antisense oligonucleotide against survivin (LY2181308) in Japanese patients with solid tumors
Background: Survivin is a protein known to regulate apoptosis and cell division and highly expressed in various types of cancers… 
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