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LXR 623

Known as: LXR-623, LXR623 
 

Topic mentions per year

Topic mentions per year

2008-2017
0120082017

Papers overview

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2017
2017
LXR agonists promote the proliferation of neural progenitor cells through MEK-ERK pathway.
The liver X receptors (LXRs) are transcriptional regulators of lipid homeostasis and may be critical for neurodegeneration and… (More)
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2016
2016
An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.
Small-molecule inhibitors targeting growth factor receptors have failed to show efficacy for brain cancers, potentially due to… (More)
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Review
2015
Review
2015
Emerging small molecule drugs.
Dyslipidaemia is a major risk factor for cardiovascular diseases. Pharmacological lowering of LDL-C levels using statins reduces… (More)
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2012
2012
Synergistic effect of liver X receptor activation and simvastatin on plaque regression and stabilization: an magnetic resonance imaging study in a model of advanced atherosclerosis.
AIMS The aim of this study was to investigate the effects of liver X receptors (LXRs)-β preferential activation by LXR-623 (WAY… (More)
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Review
2010
Review
2010
Liver X receptor modulators: a review of recently patented compounds (2007 - 2009).
IMPORTANCE OF THE FIELD Liver X receptors (LXRs) are ligand activated transcription factors involved in cholesterol metabolism… (More)
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2009
2009
Safety, pharmacokinetics, and pharmacodynamics of single doses of LXR-623, a novel liver X-receptor agonist, in healthy participants.
Liver X-receptor (LXR) agonists have been postulated to enhance reverse cholesterol transport (RCT), a process believed to… (More)
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2009
2009
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse.
Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation of gene expression involved in… (More)
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2008
2008
Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells
LXRs (Liver X Receptor α and β) are nuclear receptors that act as ligand-activated transcription factors. LXR activation causes… (More)
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