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Growing evidence indicates that clear cell renal cell carcinoma (ccRCC) is a metabolism-related disease. Changes in fatty acid… Expand LXR-623 (WAY-252623), a liver X receptor agonist, reduces atherosclerotic plaque progression and remarkably inhibits the… Expand Cholesterol is a pivotal factor for cancer cells to entertain their relentless growth. In this case, we provide a novel strategy… Expand Small-molecule inhibitors targeting growth factor receptors have failed to show efficacy for brain cancers, potentially due to… Expand Liver X receptors (LXR) are members of the nuclear receptor family. As activated transcription factors, their putative… Expand AIMS
The aim of this study was to investigate the effects of liver X receptors (LXRs)-β preferential activation by LXR-623 (WAY… Expand Importance of the field: Liver X receptors (LXRs) are ligand activated transcription factors involved in cholesterol metabolism… Expand Liver X‐receptor (LXR) agonists have been postulated to enhance reverse cholesterol transport (RCT), a process believed to… Expand Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation of gene expression involved in… Expand BackgroundLXRs (Liver X Receptor α and β) are nuclear receptors that act as ligand-activated transcription factors. LXR… Expand