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LXR 623

Known as: LXR-623, LXR623 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Targeting the transcription factor receptor LXR to treat clear cell renal cell carcinoma: agonist or inverse agonist?
Growing evidence indicates that clear cell renal cell carcinoma (ccRCC) is a metabolism-related disease. Changes in fatty acid… 
2019
2019
The LXR-623-induced long non-coding RNA LINC01125 suppresses the proliferation of breast cancer cells via PTEN/AKT/p53 signaling pathway
LXR-623 (WAY-252623), a liver X receptor agonist, reduces atherosclerotic plaque progression and remarkably inhibits the… 
2019
2019
SIRT2 plays a novel role on progesterone, estradiol and testosterone synthesis via PPARs/LXRα pathways in bovine ovarian granular cells
2019
2019
Activation of LXR Receptors and Inhibition of TRAP1 Causes Synthetic Lethality in Solid Tumors
Cholesterol is a pivotal factor for cancer cells to entertain their relentless growth. In this case, we provide a novel strategy… 
Highly Cited
2016
Highly Cited
2016
An LXR-Cholesterol Axis Creates a Metabolic Co-Dependency for Brain Cancers.
Review
2012
Review
2012
Selective liver X receptor modulators (SLiMs): What use in human health?
Review
2010
Review
2010
Liver X receptor modulators: a review of recently patented compounds (2007 – 2009)
Importance of the field: Liver X receptors (LXRs) are ligand activated transcription factors involved in cholesterol metabolism… 
Highly Cited
2009
Highly Cited
2009
Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of LXR‐623, a Novel Liver X‐Receptor Agonist, in Healthy Participants
Liver X‐receptor (LXR) agonists have been postulated to enhance reverse cholesterol transport (RCT), a process believed to… 
Highly Cited
2009
Highly Cited
2009
LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse[S]
Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation of gene expression involved in… 
2008
2008
Discovery and implementation of transcriptional biomarkers of synthetic LXR agonists in peripheral blood cells
BackgroundLXRs (Liver X Receptor α and β) are nuclear receptors that act as ligand-activated transcription factors. LXR… 
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