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LT175

National Institutes of Health

Papers overview

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2014
2014
LT175 Is a Novel PPARα/γ Ligand with Potent Insulin-sensitizing Effects and Reduced Adipogenic Properties*
Background: PPARs are attractive targets of antidiabetic agents. However, PPAR ligands show side effects that hinder their… 
2014
2014
Structural basis of the transactivation deficiency of the human PPARγ F360L mutant associated with familial partial lipodystrophy.
The peroxisome proliferator-activated receptors (PPARs) are transcription factors that regulate glucose and lipid metabolism. The… 
2013
2013
DESIGN, SYNTHESIS AND BIOLOGICAL EVALUATION OF NEW ANALOGS OF THE DUAL PPARalpha/gamma AGONIST LT175
2012
2012
PPAR ACTIVATION BY LT 175 , A NOVEL DUAL PPAR α / γ LIGAND THAT AMELIORATES THE METABOLIC PROFILE AND INSULIN SENSITIVITY IN A MOUSE MODEL OF INSULIN
2010
2010
LT175, a dual PPAR ligand, increases energy metabolism and improves the diabetic phenotype in different mouse models
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