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LT1009

National Institutes of Health

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Broader (1)

Sonepcizumab

Papers overview

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2020
2020
Ion Binding Properties of a Naturally Occurring Metalloantibody
LT1009 is a humanized version of murine LT1002 IgG1 that employs two bridging Ca2+ ions to bind its antigen, the biologically… 
2014
2014
A multicenter, open-label, single-arm, phase 2 study of the S1P inhibitor sonepcizumab (LT1009) in patients with previously treated metastatic renal cell carcinoma (mRCC).
TPS4605 Background: Sphingosine-1-phosphate (S1P), a key component of the sphingolipid signaling cascade, is a pleiotropic… 
2010
2010
Production and characterization of monoclonal anti-sphingosine-1-phosphate antibodies 1
Sphingosine-1-phospate (S1P) is a bioactive lysophospholipid signaling molecule that serves important roles in normal development… 
Highly Cited
2009
Highly Cited
2009
The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen
The pleiotropic signaling lipid sphingosine-1-phosphate (S1P) plays significant roles in angiogenesis, heart disease, and cancer… 
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