FAQ

LMO1 protein, human

Known as: LMO1, Cysteine-Rich Protein TTG-1, LIM domain only 1 (rhombotin 1) protein, human 
Rhombotin-1 (156 aa, ~18 kDa) is encoded by the human LMO1 gene. This protein is involved in transcriptional regulation.

Topic mentions per year

Topic mentions per year

1995-2017
051019952017

Related topics

Related topics

11 relations
Cell ProliferationDNA-Binding ProteinsGenes, RegulatorHomo sapiens
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Broader (2)

LIM Domain ProteinsTRANSCRIPTION FACTOR

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
LMO1 protein, human
TRANSCRIPTION FACTOR
Cell Proliferation
dna binding
Homo sapiens
Genes, Regulator

Papers overview

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2015
2015
Genetic predisposition to neuroblastoma mediated by a LMO1 super-enhancer polymorphism.
Neuroblastoma is a paediatric malignancy that typically arises in early childhood, and is derived from the developing sympathetic… (More)
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2014
2014
SCL, LMO1 and Notch1 Reprogram Thymocytes into Self-Renewing Cells
The molecular determinants that render specific populations of normal cells susceptible to oncogenic reprogramming into self… (More)
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Highly Cited
2011
Highly Cited
2011
Integrative genomics identifies LMO1 as a neuroblastoma oncogene.
Neuroblastoma is a childhood cancer of the sympathetic nervous system that accounts for approximately 10% of all paediatric… (More)
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2010
2010
Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.
Deciphering molecular events required for full transformation of normal cells into cancer cells remains a challenge. In T-cell… (More)
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2004
2004
Null mutation of the Lmo4 gene or a combined null mutation of the Lmo1/Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice.
The LIM-only family of proteins comprises four members; two of these (LMO1 and LMO2) are involved in human T-cell leukemia via… (More)
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Highly Cited
2000
Highly Cited
2000
SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-Tα chain expression
Cooperation between the stem cell leukemia (SCL) transcription factor and its nuclear partners LMO1 or LMO2 induces aggressive T… (More)
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1999
1999
Disordered T-cell development and T-cell malignancies in SCL LMO1 double-transgenic mice: parallels with E2A-deficient mice.
The gene most commonly activated by chromosomal rearrangements in patients with T-cell acute lymphoblastic leukemia (T-ALL) is… (More)
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1998
1998
Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.
LMO4 is a novel member of the LIM-only (LMO) subfamily of LIM domain-containing transcription factors. LMO1, LMO2, and LMO4 have… (More)
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1998
1998
The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)
The ectopic expression of LMO1 or LMO2 in T cell acute leukaemias resulting from chromosomal translocations t(11;14)(p15;q11) or… (More)
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Highly Cited
1997
Highly Cited
1997
An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.
The product of the scl (also called tal-1 or TCL5) gene is a basic domain, helix-loop-helix (bHLH) transcription factor required… (More)
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