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LIMS1 wt Allele

Known as: PINCH1, PINCH-1, PINCH 
Human LIMS1 wild-type allele is located within 2q12.3-q13 and is approximately 150 kb in length. This allele, which encodes LIM and senescent cell… 
National Institutes of Health

Related topics

Related topics

5 relations
2q12.2Homo sapiensSignal Transductionprotein protein interaction

Broader (1)

LIMS1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Focal adhesion proteins Pinch1 and Pinch2 regulate bone homeostasis in mice.
Mammalian focal adhesion proteins Pinch1 and Pinch2 regulate integrin activation and cell-extracellular matrix adhesion and… 
Highly Cited
2009
Highly Cited
2009
Targeted Ablation of PINCH1 and PINCH2 From Murine Myocardium Results in Dilated Cardiomyopathy and Early Postnatal Lethality
Background— PINCH proteins are 5 LIM domain–only adaptor proteins that function as key components of the integrin signaling… 
Highly Cited
2008
Highly Cited
2008
PINCH-1 Regulates the ERK-Bim Pathway and Contributes to Apoptosis Resistance in Cancer Cells*
Resistance to apoptosis is a hallmark of cancer cells. We report here that PINCH-1, a cytoplasmic component of cell-extracellular… 
2007
2007
Pinch1 Is Required for Normal Development of Cranial and Cardiac Neural Crest–Derived Structures
Pinch1, an adaptor protein composed of 5 LIM domains, has been suggested to play an important role in multiple cellular processes… 
Highly Cited
2006
Highly Cited
2006
Warrior Ascetics and Indian Empires
1. Mughal Yogis 2. WarLords 3. Company Gosains 4. Begams and Ranis in Rasdhan 5. Sakti Bhakti 6. Indian Sadhus Kailash's… 
Highly Cited
2005
Highly Cited
2005
PINCH1 Plays an Essential Role in Early Murine Embryonic Development but Is Dispensable in Ventricular Cardiomyocytes
ABSTRACT PINCH1, an adaptor protein composed of five LIM domains, mediates protein-protein interactions and functions as a… 
Highly Cited
2005
Highly Cited
2005
PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage
PINCH1 is composed of 5 LIM domains, binds integrin-linked kinase (ILK) and locates to integrin-mediated adhesion sites. In order… 
Highly Cited
2004
Highly Cited
2004
Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival.
Proteins at cell-extracellular matrix adhesions (e.g. focal adhesions) are crucially involved in regulation of cell morphology… 
Highly Cited
2003
Highly Cited
2003
PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival*
PINCH-1 is a widely expressed focal adhesion protein that forms a ternary complex with integrin-linked kinase (ILK) and CH-ILKBP… 
Highly Cited
2003
Highly Cited
2003
PINCH2 is a new five LIM domain protein, homologous to PINCHand localized to focal adhesions.
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